4-Chloracetamino-<1>naphthol | 6683-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-Chloracetamino-<1>naphthol
• 英文别名: chloro-acetic acid-(4-hydroxy-[1]naphthylamide)；Chlor-essigsaeure-(4-hydroxy-[1]naphthylamid)；4-Chloracetamino-naphthol-(1)；2-Chloro-n-(4-hydroxynaphthalen-1-yl)acetamide
• CAS: 6683-64-3
• 化学式: C₁₂H₁₀ClNO₂
• 分子量: 235.67
• InChiKey: DEJFTSYOXKEIDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氨基-1-萘酚 、 氯乙酰氯 在 sodium acetate 、 溶剂黄146 作用下， 生成 4-Chloracetamino-<1>naphthol
  参考文献：
  名称：

  Jacobs; Heidelberger; Rolf, Journal of the American Chemical Society, 1919, vol. 41, p. 460

  摘要：

  DOI：

文献信息

• N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION
  申请人：Aktas Bertal Huseyin

  公开号：US20120115915A1

  公开（公告）日：2012-05-10

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

  本文提供了抑制翻译起始的组合物和方法。描述了使用N，N'-二芳基脲和/或N，N'-二芳基硫脲化合物治疗（1）细胞增生性疾病，（2）非增生性退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。
• Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0603953A1

  公开（公告）日：1994-06-29

  Aqueous compositions, test kits, test devices and methods can be used to detect hydrogen peroxide or peroxidase by generating a colorimetric or chemiluminescent signal in the presence of the analyte. Signal generation is enhanced by the presence of certain substituted 4-hydroxy- or 4-alkoxy-substituted phenyl or naphthyl electron transfer agents.

  水性组合物、检测试剂盒、检测设备和方法可用于检测过氧化氢或过氧化物酶，在被分析物存在的情况下产生比色或化学发光信号。某些取代的 4-羟基或 4-烷氧基取代的苯基或萘基电子转移剂的存在可增强信号的产生。
• Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0603954A2

  公开（公告）日：1994-06-29

  A dry analytical element can be used to sensitively and rapidly detect a wide variety of specific binding ligands in either a competitive binding or sandwich assay format. The assays are carried out using a peroxidase-labeled immunoreactant. The peroxidase label is stabilized with a 4-hydroxy or 4-alkoxyarylacetamide which is located in one or more zones of the element. Not only is the label stabilized with the stabilizer, but the assay is more sensitive.

  干式分析元件可用于以竞争性结合或夹心检测的形式灵敏、快速地检测各种特异性结合配体。检测使用过氧化物酶标记的免疫反应物。过氧化物酶标签用 4-羟基或 4-烷氧基芳基乙酰胺稳定，这种乙酰胺位于元件的一个或多个区域。使用稳定剂不仅可以稳定标签，还能提高检测灵敏度。
• Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0603954B1

  公开（公告）日：2000-03-08
• N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation
  申请人：President and Fellows of Harvard College

  公开号：US20160318857A1

  公开（公告）日：2016-11-03

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.