N,N-dibutyl-N'-methyl-propanediyldiamine | 189625-05-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dibutyl-N'-methyl-propanediyldiamine
• 英文别名: N,N-Dibutyl-N'-methyl-propandiyldiamin；1,3-Propanediamine, N,N-dibutyl-N'-methyl-；N',N'-dibutyl-N-methylpropane-1,3-diamine
• CAS: 189625-05-6
• 化学式: C₁₂H₂₈N₂
• 分子量: 200.368
• InChiKey: JGDRVSWEZYEQOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-dibutyl-N'-methyl-propanediyldiamine 、 苯甲酰氯 生成
  参考文献：
  名称：

  Long-range anisotropic effects of long chain amides

  摘要：

  DOI：

  10.1007/bf00899784
• 作为产物：
  描述：

  3-(二丁胺)丙胺 在 lithium aluminium tetrahydride 作用下， 生成 N,N-dibutyl-N'-methyl-propanediyldiamine
  参考文献：
  名称：

  Long-range anisotropic effects of long chain amides

  摘要：

  DOI：

  10.1007/bf00899784

文献信息

• Quinazoline derivatives useful in cancer treatment
  申请人：Mallams K. Alan

  公开号：US20070032502A1

  公开（公告）日：2007-02-08

  The present invention provides compounds of Formula I (wherein X, m, R 1 , R 2 , R 3 , and R 4 are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.

  本发明提供了公式I的化合物（其中X、m、R1、R2、R3和R4如本文所定义）或其药学上可接受的盐、溶剂或酯。本发明还提供了包含这些化合物的组合物，这些组合物对于治疗细胞增殖性疾病、与p53突变体活性有关的疾病或导致癌细胞凋亡具有用处。
• Ethylene alpha-olefin mannich base viscosity index improver/dispersant additives
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0357215A1

  公开（公告）日：1990-03-07

  The present invention is directed to oil-soluble lubricating oil viscosity index improver/dispersant additives comprising Mannich Base condensates of a grafted ethylene copolymer, an optionally alkyl-substituted N-hydroxyaryl compound, an aldehdye, and a monosecondary amine, whereby oil solutions, particularly oil concentrates, of said additives which are characterized by minimal viscosity change over an extended period of time. These additives comprise a copolymer of ethylene with one or more C3 to C28 alpha-olefins, preferably propylene, which have been grafted with acid moieties, e.g. maleic anhydride, preferably using a free radical initiator in a solvent such as a lubricating oil, which is then either (a) reacted with an N-hydroxyaryl amine and then condensed with an aldehyde and a monosecondary amine to form the Mannich Base viscosity index improver/dispersant material, or (b) reacted with a preformed Mannich Base condensate of an N-hydroxyaryl amine. aldehyde and the monosecondary amine. The invention also relates to process for preparing the preceding products and their use in oil compositions.

  本发明涉及油溶性润滑油粘度指数改进剂/分散剂添加剂，该添加剂由接枝乙烯共聚物、任选烷基取代的 N-羟基芳基化合物、醛染料和单仲胺的曼尼希碱缩合物组成。这些添加剂包括乙烯与一种或多种 C3 至 C28 α-烯烃（最好是丙烯）的共聚物，该共聚物已与酸接枝，例如马来酸酐，最好在润滑油等溶剂中使用自由基引发剂，然后(a) 与 N-羟基芳基胺反应，再与醛和单仲胺缩合，形成曼尼希碱粘度指数改进剂/分散剂材料，或 (b) 与 N-羟基芳基胺、醛和单仲胺的预制曼尼希碱缩合物反应。本发明还涉及上述产品的制备工艺及其在油类组合物中的用途。
• Quinazoline Derivatives.¹ I. The Synthesis of 4-(4'-Diethylamino-1'-methylbutyl-amino)-quinazoline (SN 11,534) and the Corresponding 2-Phenylquinazoline (SN 11,535)²
  作者：Margaret M. Endicott、Emily Wick、Marie L. Mercury、Mary L. Sherrill

  DOI：10.1021/ja01211a055

  日期：1946.7
• UNSYMMETRICALLY SUBSTITUTED DICARBOXYLIC ACID DIAMIDO AMMONIUM SALTS AND THEIR USE FOR GAS HYDRATE ANTI-AGGLOMERATION
  申请人：Clariant International Ltd

  公开号：EP3864108B1

  公开（公告）日：2022-06-15
• PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RESTORING BETA-CELL MASS AND FUNCTION
  申请人：NADLER Jerry L.

  公开号：US20080300189A1

  公开（公告）日：2008-12-04

  Pharmaceutical compositions and methods for using are provided for restoring β-cell mass and function in a mammal in need thereof. The pharmaceutical compositions have a biological response modifier and a β-cell growth factor in admixture with a pharmaceutically acceptable carrier, adjuvant or vehicle.