2-<4-Methoxy-phenyl>-N-methyl-piperidin | 2810-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-<4-Methoxy-phenyl>-N-methyl-piperidin
• 英文别名: 2-(4-methoxy-phenyl)-1-methyl-piperidine；2-(4-Methoxy-phenyl)-1-methyl-piperidin；2-(4-Methoxyphenyl)-1-methylpiperidine
• CAS: 2810-01-7
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: KSVIBVRZHTZGFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(4-甲氧基苄基)甲酰胺 在 叔丁基锂 、 triethyloxonium fluoroborate 、 potassium hydride 、 一水合肼 作用下， 以 四氢呋喃 、 乙醇 、 溶剂黄146 为溶剂， 反应 9.5h， 生成 2-<4-Methoxy-phenyl>-N-methyl-piperidin
  参考文献：
  名称：

  Formamidines as α-amino carbanion precursors. The synthesis of 2-arylpiperidines, -pyrrolidines, and nicotine analogs

  摘要：

  DOI：

  10.1016/s0040-4039(00)98247-9

文献信息

• NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION
  申请人：Oshima Kunio

  公开号：US20120225866A1

  公开（公告）日：2012-09-06

  The present invention provides a novel diazepine compound that blocks the I Kur current or the Kv1.5 channel potently and more selectively than other K + channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R 2 and R 3 may be linked to form lower alkylene; A 1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y 1 and Y 2 are each independently —N═ or —CH═; and R 5 is group represented by wherein R 6 and R 7 are each independently hydrogen or organic group; R 6 and R 7 may be linked to form a ring together with the neighboring group —X A —N—X B —; X A and X B are each independently a bond, lower alkylene, etc.

  本发明提供了一种新型的二氮杂环化合物，它可以有效地阻断IKur电流或Kv1.5通道，并比其他K+通道更具选择性。本发明涉及一种由通式（1）表示的二氮杂环化合物或其盐，其中R1、R2、R3和R4各自独立地表示氢、低碳基、环状低碳基或低烷氧基低碳基；R2和R3可以连接形成低碳烷基；A1是低碳烷基，可选地取代一个或多个羟基和氧代基；Y1和Y2各自独立地表示—N═或—CH═；R5是由下式表示的基：其中R6和R7各自独立地表示氢或有机基团；R6和R7可以与相邻的基团—XA—N—XB—一起形成环；XA和XB各自独立地表示键、低碳烷基等。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP3747885A1

  公开（公告）日：2020-12-09

  The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

  本发明提供了一种具有降低葡萄糖酰胺作用（如促进葡萄糖酰胺代谢、抑制葡萄糖酰胺合成、促进葡萄糖酰胺分解等）的化合物，有望作为预防或治疗溶酶体疾病（如、戈谢病）、神经退行性疾病（如帕金森病、路易体痴呆、多系统萎缩）等。 本发明涉及一种由式（I）代表的化合物： 其中各符号如说明书所述，或其盐。
• PIPERIDINE DERIVATIVES. PART II. 2-PHENYL- AND 2-PHENYLALKYL-PIPERIDINES¹
  作者：JOHN LEE、ALBERT ZIERING、STEPHEN D. HEINEMAN、LEO BERGER

  DOI：10.1021/jo01170a021

  日期：1947.11
• US20140343278A1
  申请人：——

  公开号：US20140343278A1

  公开（公告）日：2014-11-20
• US20140343277A1
  申请人：——

  公开号：US20140343277A1

  公开（公告）日：2014-11-20