3α,7α,12α-trihydroxy-5β-cholestan-24-one | 97925-10-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α,7α,12α-trihydroxy-5β-cholestan-24-one
• 英文别名: 3α,7α,12α-Trihydroxy-5β-cholestan-24-on；3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-24-one；(6R)-2-methyl-6-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptan-3-one
• CAS: 97925-10-5
• 化学式: C₂₇H₄₆O₄
• 分子量: 434.66
• InChiKey: ARCPYLSHVXKOSK-ZKATULPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3α,7α,12α-trihydroxy-5β-cholestan-24-one 在 chromium(VI) oxide 、 sodium hydroxide 、 肼 、 三乙二醇 作用下， 反应 2.0h， 生成 5β-cholestane-3,7,12-trione
  参考文献：
  名称：

  Seno, Proceedings of the Japan Academy, 1954, vol. 30, p. 887,889

  摘要：

  DOI：
• 作为产物：
  描述：

  cadmium(2+),propane 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 苯 作用下， 生成 3α,7α,12α-trihydroxy-5β-cholestan-24-one
  参考文献：
  名称：

  PREPARATION OF 3α,7α,12α-TRIHYDROXY-24α-OXOCOPROSTANE AND 3α,7α,12α,24ξ-TETRAHYDROXYCOPROSTANE

  摘要：

  DOI：

  10.1093/oxfordjournals.jbchem.a126906

文献信息

• Functional segregated telodendrimers and nanocarriers and methods of making and using same
  申请人：The Research Foundation for the State University of New York

  公开号：US10463694B2

  公开（公告）日：2019-11-05

  Provided are multiply functional telodendrimers. The telodendrimers can be used for combination drug delivery. The telodendrimers may have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as combinations of drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.

  本文提供了具有多重功能的端树枝状聚合物。这些端树状聚合物可用于联合给药。端二聚三聚物可具有一个或多个交联基团（如可逆光交联基团）。端二聚三聚物可以聚集形成纳米载体。药物组合、成像探针和其他材料等载体可通过与端树枝形聚分子的非共价或共价相互作用被封存在聚合体的核心部分。这种纳米载体可用于药物输送和成像应用。
• Functional, segregated, charged telodendrimers and nanocarriers and methods of making and using same
  申请人：The Research Foundation for the State University of New York

  公开号：US10947350B2

  公开（公告）日：2021-03-16

  Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.

  本文提供的是多官能团带电端树枝状聚合物。这些端树枝状聚合物可用于蛋白质的封装和输送。带电的端二聚体可具有一个或多个交联基团（如硼酸/邻苯二酚可逆交联基团）。端二聚物可聚集形成纳米颗粒。蛋白质和其他材料的组合等货物可通过与端二聚体的非共价或共价相互作用被封存在纳米颗粒的核心中。这种纳米颗粒可用于蛋白质输送应用。
• Telodendrimers with riboflavin moieties and nanocarriers and methods of making and using same
  申请人：The Research Foundation for the State University of New York

  公开号：US11369614B2

  公开（公告）日：2022-06-28

  Provided herein are compositions and nanocarriers comprising linear-dendritic telodendrimers (TD) containing riboflavin. The nanocarriers and compositions have desirable loading properties and stabilized structure and can be used for efficient in vivo delivery.

  本文提供了由含有核黄素的线性树枝状端粒（TD）组成的组合物和纳米载体。这些纳米载体和组合物具有理想的装载特性和稳定的结构，可用于体内高效给药。
• TELODENDRIMERS AND NANOCARRIERS AND METHODS OF USING SAME
  申请人：The Research Foundation for the State University of New York

  公开号：US20150056139A1

  公开（公告）日：2015-02-26

  Provided are functional segregated telodendrimers having, for example, two or three functional segments. The telodendrimers can have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.
• FUNCTIONAL SEGREGATED TELODENDRIMERS AND NANOCARRIERS AND METHODS OF MAKING AND USING SAME
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US20170252456A1

  公开（公告）日：2017-09-07

  Provided are multiply functional telodendrimers. The telodendrimers can be used for combination drug delivery. The telodendrimers may have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as combinations of drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.