6-羟基哌啶-2-酮 | 1314922-51-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 6-羟基哌啶-2-酮
• 英文名称: 6-hydroxy-2-piperidone
• 英文别名: 6-Hydroxypiperidin-2-one
• CAS: 1314922-51-4
• 化学式: C₅H₉NO₂
• 分子量: 115.132
• InChiKey: FJJNBBZIQAVJPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-羟基哌啶-2-酮 在 对甲苯磺酸 作用下， 生成 3,4-二氢-2(1H)-吡啶酮
  参考文献：
  名称：

  Unsaturated Lactams: New Inputs for Povarov-Type Multicomponent Reactions

  摘要：

  Unsaturated lactams with endo- or exocyclic C-C double bonds constitute a set of reactive inputs that serve as the electron-rich olefin component in Povarov reactions. These substrates afford the multicomponent adducts in convenient yields and offer a wide range of structural diversity. Postcondensation transformations allow direct access to a variety of lactam-fused and amide-substituted quinoline derivatives.

  DOI：

  10.1021/ol902913j
• 作为产物：
  描述：

  戊二酰亚胺 在 sodium tetrahydroborate 作用下， 生成 6-羟基哌啶-2-酮
  参考文献：
  名称：

  Unsaturated Lactams: New Inputs for Povarov-Type Multicomponent Reactions

  摘要：

  Unsaturated lactams with endo- or exocyclic C-C double bonds constitute a set of reactive inputs that serve as the electron-rich olefin component in Povarov reactions. These substrates afford the multicomponent adducts in convenient yields and offer a wide range of structural diversity. Postcondensation transformations allow direct access to a variety of lactam-fused and amide-substituted quinoline derivatives.

  DOI：

  10.1021/ol902913j

文献信息

• Unsaturated Lactams: New Inputs for Povarov-Type Multicomponent Reactions
  作者：Esther Vicente-García、Federica Catti、Rosario Ramón、Rodolfo Lavilla

  DOI：10.1021/ol902913j

  日期：2010.2.19

  Unsaturated lactams with endo- or exocyclic C-C double bonds constitute a set of reactive inputs that serve as the electron-rich olefin component in Povarov reactions. These substrates afford the multicomponent adducts in convenient yields and offer a wide range of structural diversity. Postcondensation transformations allow direct access to a variety of lactam-fused and amide-substituted quinoline derivatives.