2-tert-butyl-dimethylsiloxy-6-(3-adamantan-1-yl-4-methoxyphenyl)-naphthalene | 869644-45-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-tert-butyl-dimethylsiloxy-6-(3-adamantan-1-yl-4-methoxyphenyl)-naphthalene
• 英文别名: [6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalen-2-yl]oxy-tert-butyl-dimethylsilane
• CAS: 869644-45-1
• 化学式: C₃₃H₄₂O₂Si
• 分子量: 498.781
• InChiKey: LMMFUUNCTHWINZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.37
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-tert-butyl-dimethylsiloxy-6-(3-adamantan-1-yl-4-methoxyphenyl)-naphthalene 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 生成 6-(3-((3r,5r,7r)-Adamantan-1-yl)-4-methoxyphenyl)naphthalen-2-ol
  参考文献：
  名称：

  WO2007/28104

  摘要：

  公开号：
• 作为产物：
  描述：

  3-(1-金刚烷基)-4-甲氧基苯硼酸 、 (6-溴萘-2-基氧基)-叔丁基二甲基硅烷 在 四(三苯基膦)钯 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.5h， 以90%的产率得到2-tert-butyl-dimethylsiloxy-6-(3-adamantan-1-yl-4-methoxyphenyl)-naphthalene
  参考文献：
  名称：

  [EN] NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS
  [FR] AGENTS THERAPEUTIQUES POUR LE TRAITEMENT DU CANCER, DES MALADIES METABOLIQUES ET DE LA PEAU

  摘要：

  本发明涉及按式（I）定义的新化合物，其中R1、R2、R3和R4如本文所定义。本发明还揭示了制备方法、药物组合物以及利用包含这些化合物的药物组合物进行疾病治疗的方法。本发明的化合物是哺乳动物主体中治疗癌症、糖尿病、代谢性疾病和皮肤疾病的新型治疗剂。这些化合物还是有用的基因表达调节剂。它们通过干扰某些细胞信号转导级联来发挥作用。因此，本发明的化合物也适用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。本发明还揭示了哺乳动物疾病的药物组合物和治疗方法。

  公开号：

  WO2005108338A1

文献信息

• [EN] NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS<br/>[FR] AGENTS THERAPEUTIQUES POUR LE TRAITEMENT DU CANCER, DES MALADIES METABOLIQUES ET DE LA PEAU
  申请人：AUSPEX PHARMACEUTICALS

  公开号：WO2005108338A1

  公开（公告）日：2005-11-17

  The present invention is directed to novel compounds according to formulae (I) wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

  本发明涉及按式（I）定义的新化合物，其中R1、R2、R3和R4如本文所定义。本发明还揭示了制备方法、药物组合物以及利用包含这些化合物的药物组合物进行疾病治疗的方法。本发明的化合物是哺乳动物主体中治疗癌症、糖尿病、代谢性疾病和皮肤疾病的新型治疗剂。这些化合物还是有用的基因表达调节剂。它们通过干扰某些细胞信号转导级联来发挥作用。因此，本发明的化合物也适用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。本发明还揭示了哺乳动物疾病的药物组合物和治疗方法。
• Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
  申请人：Sarshar Sepehr

  公开号：US20070078189A1

  公开（公告）日：2007-04-05

  The present invention is directed to novel compounds according to formulae wherein R 1 , R 2 , R 3 and R 4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

  本发明涉及公式（I）所示的新化合物，其中R1，R2，R3和R4如本文所定义。本发明还揭示了制备方法，制药组合物以及利用包含这些化合物的制药组合物的疾病治疗方法。本发明的化合物是哺乳动物主体中用于治疗癌症，糖尿病，代谢性疾病和皮肤疾病的新型治疗剂。这些化合物也是有用的基因表达调节剂。它们通过干扰某些细胞信号转导级联来发挥其活性。因此，本发明的化合物也有助于调节受各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。本发明还揭示了哺乳动物疾病的制药组合物和治疗方法。
• Novel Therapeutic Agents for the Treatment of Cancer, Metabolic Diseases and Skin Disorders
  申请人：Sarshar Sepehr

  公开号：US20080221069A1

  公开（公告）日：2008-09-11

  The present invention is directed to novel compounds according to formula (I) wherein R 1 , R 2 , and X are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

  本发明涉及按照式（I）定义的新化合物，其中R1、R2和X如本文所定义。本发明还揭示了制备方法、制药组合物以及利用包含这些化合物的制药组合物治疗疾病的方法。本发明的化合物是哺乳动物主体中治疗癌症、糖尿病、代谢疾病和皮肤疾病的新型治疗剂。这些化合物也是有用的基因表达调节剂。它们通过干扰某些细胞信号转导级联来发挥作用。因此，本发明的化合物也有助于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。本发明还揭示了哺乳动物疾病的制药组合物和治疗方法。
• Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
  申请人：Auspex Pharmaceuticals

  公开号：US07468462B2

  公开（公告）日：2008-12-23

  The present invention is directed to novel compounds according to formulae wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

  本发明涉及按照公式所示的新化合物，其中R1、R2、R3和R4如本文所定义。该发明还揭示了制备方法，制药组合物以及利用这些化合物组成的制药组合物治疗疾病的方法。本发明的化合物是哺乳动物主体中治疗癌症、糖尿病、代谢性疾病和皮肤疾病的新型治疗剂。这些化合物也是有用的基因表达调节剂。它们通过干扰某些细胞信号转导级联来发挥作用。本发明的化合物因此也用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。该发明还揭示了哺乳动物疾病的制药组合物和治疗方法。
• WO2007/28104
  申请人：——

  公开号：——

  公开（公告）日：——