1.2-Bis--ethan | 23707-53-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 1.2-Bis--ethan
• 英文别名: [Cyclohexyloxy(2-dicyclohexyloxyphosphorylethyl)phosphoryl]oxycyclohexane
• CAS: 23707-53-1
• 化学式: C₂₆H₄₈O₆P₂
• 分子量: 518.611
• InChiKey: GEKXTEMIICUHQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1.2-Bis--ethan 生成 1.2-Bis--ethan
  参考文献：
  名称：

  Petrov,K.A. et al., Journal of general chemistry of the USSR, 1969, vol. 39, p. 809 - 811

  摘要：

  DOI：
• 作为产物：
  描述：

  dicyclohexyl hydrogen phosphite 、 1,2-二氯乙烷 生成 1.2-Bis--ethan
  参考文献：
  名称：

  Petrov,K.A. et al., Journal of general chemistry of the USSR, 1969, vol. 39, p. 809 - 811

  摘要：

  DOI：

文献信息

• Facile synthesis of symmetric esters of alkylenebisphosphonic acids
  申请人：——

  公开号：US20030060648A1

  公开（公告）日：2003-03-27

  A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.

  本文披露了一种对称的C1-C10烷基双膦酸酯的简便合成方法，其中C1-C10烷基双(膦酸二氯化物)与醇在无极性溶剂中，在1H-四唑催化剂和碱的存在下反应形成第一反应混合物。第一反应混合物维持一定时间，形成C1-C10烷基双(氯酯膦酸酯)，在碱性条件下与过量的羟基化合物反应形成第二反应混合物，第二反应混合物维持一定时间，形成C1-C10烷基双(酯膦酸酯)部分酯、同配体四酯或混合四酯。所形成的材料可以回收或直接使用。
• US6909010B2
  申请人：——

  公开号：US6909010B2

  公开（公告）日：2005-06-21
• [EN] A FACILE SYNTHESIS OF SYMMETRIC ESTERS OF ALKYLENEBISPHOSPHONIC ACIDS<br/>[FR] SYNTHESE FACILE D'ESTERS SYMETRIQUES D'ACIDES D'ALCOYLENE BISPHOSPHONIQUES
  申请人：UNIV LOYOLA CHICAGO

  公开号：WO2002085918A1

  公开（公告）日：2002-10-31

  A facile synthesis of symmetric esters of C1-C10 alkylenebisphopshonic acids is disclosed in which a C1-C10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an apro tic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C1-C10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C1-C10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.