N-(2-氨基乙基)-1,4-苯二胺 | 19201-32-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-氨基乙基)-1,4-苯二胺
• 英文名称: 1-Amino-4-(2-amino-aethylamino)-benzol
• 英文别名: N-(4-aminophenyl)-1,2-ethanediamine；4-(2'-aminoethyl)aminoaniline；N-(2-amino-ethyl)-p-phenylenediamine；N-(2-Amino-aethyl)-p-phenylendiamin；N-(2-aminoethyl)-N-(4-aminophenyl)amine；4-aminophenyl-ethylenediamine；Ethylenediamine, N-(4-aminophenyl)-；4-N-(2-aminoethyl)benzene-1,4-diamine
• CAS: 19201-32-2
• 化学式: C₈H₁₃N₃
• 分子量: 151.211
• InChiKey: TVARKMCEMIFLIP-UHFFFAOYSA-N

物化性质

• 沸点：
  343.2±22.0 °C(Predicted)
• 密度：
  1.151±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N1-(4-硝基苯基)-1,2-乙二胺 在 盐酸 、 tin(ll) chloride 作用下， 生成 N-(2-氨基乙基)-1,4-苯二胺
  参考文献：
  名称：

  Fourneau; de Lestrange, Bulletin de la Societe Chimique de France, 1947, p. 827,829,832

  摘要：

  DOI：

文献信息

• [EN] FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS<br/>[FR] COMPOSÉS CONDENSÉS DE PYRIDINE, DE PYRIMIDINE ET DE TRIAZINE EN TANT QU'INHIBITEURS DU CYCLE CELLULAIRE
  申请人：AMGEN INC

  公开号：WO2009085185A1

  公开（公告）日：2009-07-09

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

  提供了一种化合物、药物组合物和方法，用于治疗CDK4介导的疾病，如癌症。所述化合物是融合的吡啶、嘧啶和三嗪衍生物。
• TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS
  申请人：WYETH LLC

  公开号：US20170119778A1

  公开（公告）日：2017-05-04

  Compounds of formula I wherein: R 1 is and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.

  式I化合物，其中：R1为，R2、R4和R6-9如本文所定义，以及其药学上可接受的盐和酯。这些化合物抑制PI3激酶和mTOR，并可用于治疗由PI3激酶和mTOR介导的疾病，例如多种癌症。本发明还公开了制备和使用这些化合物的方法。此外，还公开了含有本发明化合物的各种组合物。
• [EN] COMPOSITION FOR DYEING KERATIN FIBRES, COMPRISING AT LEAST ONE PARA-PHENYLENEDIAMINE DERIVATIVE<br/>[FR] COMPOSITION POUR COLORER DES FIBRES DE KERATINE COMPRENANT AU MOINS UN DERIVE DE PARA-PHENYLENEDIAMINE
  申请人：OREAL

  公开号：WO2005068431A1

  公开（公告）日：2005-07-28

  The invention relates to a composition for dyeing keratin fibres, and in particular human keratin fibres such as the hair, comprising at least one paraphenylenediamine derivative one amine which is included in a ring of heptamethyleneimine type, as oxidation base. The present invention makes it possible in particular to obtain strong, unselective and colourfast dyeing of keratin fibres.

  该发明涉及一种用于染色角蛋白纤维的组合物，特别是人类角蛋白纤维，如头发，包括至少一种对苯二胺衍生物，一种胺，该胺包含在七亚甲基亚胺环中，作为氧化基。本发明特别能够实现对角蛋白纤维进行强力、非选择性和耐色染色。
• Sulfur-containing secondary para-phenylenediamines dye compositions comprising such para-phenylenediamines, processes, and uses thereof
  申请人：Sabelle Stephane

  公开号：US20060005321A1

  公开（公告）日：2006-01-12

  The present disclosure relates to a novel family of sulfur-containing secondary para-phenylenediamines, to processes for preparing them, to compositions for dyeing keratin fibers, for example keratin fibers such as the hair, comprising, in a suitable dyeing medium, at least such one sulfur-containing secondary para-phenylenediamine. The present disclosure also relates to processes for dyeing keratin fibers with the compositions according to the present disclosure and to multi-compartment dyeing kits containing such compositions.

  本公开涉及一种新型含硫次级对苯二胺家族，涉及其制备过程，涉及用于染色角蛋白纤维的组合物，例如角蛋白纤维，如头发，包括在适当的染色介质中，至少含有这样一种含硫次级对苯二胺。本公开还涉及使用本公开的组合物染色角蛋白纤维的方法，以及含有这种组合物的多室染色套装。
• [EN] TRIAROMATIC AZOMETHINE DIRECT DYES, DYE COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USE<br/>[FR] COLORANTS DIRECTS D'AZOMÉTHINE TRIAROMATIQUES, COMPOSITION DE COLORANT COMPRENANT AU MOINS L'UN DE CES COLORANTS, LEUR PROCÉDÉ DE MISE EN OEUVRE ET LEUR UTILISATION
  申请人：OREAL

  公开号：WO2013087768A1

  公开（公告）日：2013-06-20

  The present invention relates to azomethine-type direct dyes having a triaromatic unit o f formula (I) below: and also the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair. The invention also relates to a composition for dyeing keratin fibres, comprising, in a medium suitable for dyeing, such direct dyes. Another subject of the present invention is a method for dyeing keratin fibres using said dye composition. Finally, the present invention also relates to precursors of these direct dyes.

  本发明涉及具有以下式（I）中的三芳基单元的偶氮亚甲基型直接染料，以及其用于染色角蛋白纤维，特别是人类角蛋白纤维如头发的用途。本发明还涉及一种用于染色角蛋白纤维的组合物，包括在适合染色的介质中的这种直接染料。本发明的另一个主题是使用所述染料组合物染色角蛋白纤维的方法。最后，本发明还涉及这些直接染料的前体。