5-[2-[10-[2-(4-aminophenyl)ethynyl]anthracen-9-yl]ethynyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | 1374418-24-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-[2-[10-[2-(4-aminophenyl)ethynyl]anthracen-9-yl]ethynyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 1374418-24-2
• 化学式: C₃₃H₂₅N₃O₅
• 分子量: 543.579
• InChiKey: AMZOQWOCNWVSBY-OJDZSJEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-[2-(10-bromoanthracen-9-yl)ethynyl]aniline 、 5-乙炔-2-脱氧尿苷 在 copper(l) iodide 、 四(三苯基膦)钯 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以25%的产率得到5-[2-[10-[2-(4-aminophenyl)ethynyl]anthracen-9-yl]ethynyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  参考文献：
  名称：

  Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives

  摘要：

  We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pK(a) of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.092

文献信息

• Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives
  作者：Yoshio Saito、Shigenori Miyamoto、Azusa Suzuki、Katsuhiko Matsumoto、Tsutomu Ishihara、Isao Saito

  DOI：10.1016/j.bmcl.2012.02.092

  日期：2012.4

  We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pK(a) of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection. (C) 2012 Elsevier Ltd. All rights reserved.