3-diphenylphosphinoyloctan-2-one | 101681-11-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-diphenylphosphinoyloctan-2-one
• 英文别名: 3-Diphenylphosphoryloctan-2-one
• CAS: 101681-11-2
• 化学式: C₂₀H₂₅O₂P
• 分子量: 328.391
• InChiKey: KSVRCNQUFHTEOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-5-diphenylphosphinoyl-4-methyldec-3-en-2-one 在 sodium hypochlorite 作用下， 以 吡啶 为溶剂， 反应 0.17h， 以30%的产率得到3-diphenylphosphinoyloctan-2-one
  参考文献：
  名称：

  Clayden, Jonathan; Collington, Eric W.; Egert, Ernst, Journal of the Chemical Society. Perkin transactions I, 1994, # 19, p. 2801 - 2810

  摘要：

  DOI：

文献信息

• Stereocontrolled (, and , ) synthesis of ⊙-hydroxyallylic sulphides
  作者：Andrew B. McElroy、Stuart Warren

  DOI：10.1016/s0040-4039(01)80927-8

  日期：1985.1

  All four isomers of substituted 3-alkylthio-4-hydroxybutenes have been synthesised: both the geometry of the double bond and the relative stereochemistry of the two chiral centres are controlled.

  已经合成了取代的3-烷硫基-4-羟基丁烯的所有四个异构体：双键的几何形状和两个手性中心的相对立体化学都受到控制。
• Control over absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry in the synthesis of allylically substituted alkenes from diphenylphosphinoyl epoxy alcohols
  作者：Jonathan Clayden、Andrew B. McElroy、Stuart Warren

  DOI：10.1039/p19950001913

  日期：——

  Regioselective ring-openings of epoxy alcohols bearing a diphenylphosphinoyl (Ph(2)PO) group give diols which can undergo stereospecific Horner-Wittig elimination. This method was used to make allylic alcohols, unsaturated beta-hydroxy sulfides, homoallylic alcohols and unsaturated amino acids, with control over their absolute (R,S), relative (syn,anti) and geometrical(E,Z) stereochemistry.
• Clayden Jonathan, Collington Eric W., Egert Ernst, McElroy Andrew B., War+, J. Chem. Soc. Perkin Trans. 1, (1994) N 19, S 2801- 2810
  作者：Clayden Jonathan, Collington Eric W., Egert Ernst, McElroy Andrew B., War+

  DOI：——

  日期：——