1-(4-bromophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol | 67000-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-bromophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol
• 英文别名: 1-(4-Bromophenyl)-2-(1,2,4-triazol-1-yl)ethanol
• CAS: 67000-90-2
• 化学式: C₁₀H₁₀BrN₃O
• 分子量: 268.113
• InChiKey: IANLAOPPFYGBHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-苯基-2-(1H-1,2,4-噻唑-1-基)乙酮 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以50%的产率得到1-(4-bromophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. X. Synthesis and antimicrobial activities of 1-phenyl-2-(1H-azol-1-yl) ethane derivatives. Anticonvulsant activity of 1-(4-methylphenyl)-2-(1H-imidazol-1-yl) ethanol

  摘要：

  The synthesis and antimicrobial activity of new phenylazolylethane derivatives are reported. Antimicrobial data in comparison with those obtained with miconazole, fluconazole, enilconazole, imazalil sulfate, pipemidic acid and minocycline showed that tested compounds generally possessed poor or weak activity. Toxicity and anticonvulsant activity of 1-(4-methylphenyl)-2-(1H-imidazol-1-yl)ethanol and structural likeness to Denzimol were also tested. The obtained results showed interesting anticonvulsant activity but only on the supraspinal region.

  DOI：

  10.1016/0223-5234(93)90110-z

文献信息

• US4102891A
  申请人：——

  公开号：US4102891A

  公开（公告）日：1978-07-25
• US4327104A
  申请人：——

  公开号：US4327104A

  公开（公告）日：1982-04-27
• US4349556A
  申请人：——

  公开号：US4349556A

  公开（公告）日：1982-09-14
• US4400388A
  申请人：——

  公开号：US4400388A

  公开（公告）日：1983-08-23
• Research on antibacterial and antifungal agents. X. Synthesis and antimicrobial activities of 1-phenyl-2-(1H-azol-1-yl) ethane derivatives. Anticonvulsant activity of 1-(4-methylphenyl)-2-(1H-imidazol-1-yl) ethanol
  作者：GC Porretta、R Fioravanti、M Biava、R Cirilli、N Simonetti、A Villa、U Bello、P Faccendini、B Tita

  DOI：10.1016/0223-5234(93)90110-z

  日期：1993.1

  The synthesis and antimicrobial activity of new phenylazolylethane derivatives are reported. Antimicrobial data in comparison with those obtained with miconazole, fluconazole, enilconazole, imazalil sulfate, pipemidic acid and minocycline showed that tested compounds generally possessed poor or weak activity. Toxicity and anticonvulsant activity of 1-(4-methylphenyl)-2-(1H-imidazol-1-yl)ethanol and structural likeness to Denzimol were also tested. The obtained results showed interesting anticonvulsant activity but only on the supraspinal region.