2-(bromomethyl)-4,7-dimethoxy-9-methyl-1,10-phenanthroline | 1352034-93-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 2-(bromomethyl)-4,7-dimethoxy-9-methyl-1,10-phenanthroline
• CAS: 1352034-93-5
• 化学式: C₁₆H₁₅BrN₂O₂
• 分子量: 347.211
• InChiKey: OKPOWNPQGYOGIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.0
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.24
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(bromomethyl)-4,7-dimethoxy-9-methyl-1,10-phenanthroline 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-((3-([2,2'-bipyridin]-6-ylmethoxy)-2,2-dimethylpropoxy)methyl)-4,7-dimethoxy-9-methyl-1,10-phenanthroline
  参考文献：
  名称：

  Air-Stable Heterobimetallic Catalysts to Effect Ni/Cr-Mediated Couplings with a ca. 1:1 Molar Ratio of Coupling Partners at Low Catalyst Loadings

  摘要：

  Two air-stable NI,Cr-heterobimetallic catalysts have been prepared from ligands 7 and 11, obtained from scyllo-inositol in four and three steps, respectively. Both catalysts smoothly promote Ni/Cr-mediated coupling reactions with a ca. 1:1 molar ratio of coupling partners. The catalyst derived from 11 exhibits a better catalytic profile, thereby allowing Ni/Cr-mediated coupling reactions to be achieved with a wide range of substrates at a low catalyst loading in an operationally simple manner.

  DOI：

  10.1021/ol202878v
• 作为产物：
  描述：

  4,7-dimethoxy-2,9-dimethyl-1,10-phenanthroline 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以24%的产率得到2-(bromomethyl)-4,7-dimethoxy-9-methyl-1,10-phenanthroline
  参考文献：
  名称：

  Air-Stable Heterobimetallic Catalysts to Effect Ni/Cr-Mediated Couplings with a ca. 1:1 Molar Ratio of Coupling Partners at Low Catalyst Loadings

  摘要：

  Two air-stable NI,Cr-heterobimetallic catalysts have been prepared from ligands 7 and 11, obtained from scyllo-inositol in four and three steps, respectively. Both catalysts smoothly promote Ni/Cr-mediated coupling reactions with a ca. 1:1 molar ratio of coupling partners. The catalyst derived from 11 exhibits a better catalytic profile, thereby allowing Ni/Cr-mediated coupling reactions to be achieved with a wide range of substrates at a low catalyst loading in an operationally simple manner.

  DOI：

  10.1021/ol202878v