1-[4-(2-Chloroethoxy)phenyl]-1-[4-(oxan-2-yloxy)phenyl]-2-phenylbutan-1-ol | 1032008-64-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[4-(2-Chloroethoxy)phenyl]-1-[4-(oxan-2-yloxy)phenyl]-2-phenylbutan-1-ol
• CAS: 1032008-64-2
• 化学式: C₂₉H₃₃ClO₄
• 分子量: 481.032
• InChiKey: WVLCYVMIHVOJET-UHFFFAOYSA-N

物化性质

• 沸点：
  604.7±55.0 °C(Predicted)
• 密度：
  1.180±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[4-(2-Chloroethoxy)phenyl]-1-[4-(oxan-2-yloxy)phenyl]-2-phenylbutan-1-ol 在 盐酸 、 水 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 Z-1-<4-(2-chloroethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene
  参考文献：
  名称：

  [EN] ENDOXIFEN METHODS AND COMPOSITIONS
  [FR] PROCÉDÉS ET COMPOSITIONS D'ENDOXIFÈNE

  摘要：

  公开号：

  WO2008070463A3
• 作为产物：
  描述：

  2-对溴苯氧基四氢吡喃 、 1-[4-(2-氯乙氧基)苯基]-2-乙基-2-苯乙酮 在 溴乙烷 、 碘 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 9.0h， 生成 1-[4-(2-Chloroethoxy)phenyl]-1-[4-(oxan-2-yloxy)phenyl]-2-phenylbutan-1-ol
  参考文献：
  名称：

  [EN] ENDOXIFEN METHODS AND COMPOSITIONS
  [FR] PROCÉDÉS ET COMPOSITIONS D'ENDOXIFÈNE

  摘要：

  公开号：

  WO2008070463A3

文献信息

• Endoxifen compositions and methods
  申请人：Jina Pharmaceuticals, Inc.

  公开号：US10376479B2

  公开（公告）日：2019-08-13

  The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E-guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.

  本发明提供了含有内酯昔芬的组合物、内酯昔芬的制剂和脂质体、制备此类制剂和制剂的方法，以及使用此类制剂和制剂治疗乳腺癌和其他乳腺疾病以及易受内酯昔芬影响的疾病。特别是，本发明的组合物包括内酯昔芬的脂质体、复合物、囊泡、乳液、胶束和混合胶束，其中组合物进一步含有各种中性或带电脂质中的任何一种，最好是胆固醇和胆固醇衍生物、甾醇、Z-和E-古杉甾酮、磷脂、脂肪酸、维生素D和维生素E。本发明提供了通过施用包含治疗有效量的内昔芬的新型制剂或组合物来治疗和预防乳腺癌及其他乳腺相关疾病的方法。
• Bioorg. Med. Chem. Lett. 2010, 20, 2665-2667
  作者：

  DOI：——

  日期：——
• ENDOXIFEN FOR USE IN THE TREATMENT OF CANCER
  申请人：Jina Pharmaceuticals Inc.

  公开号：EP2101731B1

  公开（公告）日：2018-01-31
• ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF PSYCHIATRIC AND NEURODEGENERATIVE DISEASES
  申请人：Ahmad Ateeq

  公开号：US20090291134A1

  公开（公告）日：2009-11-26

  The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of a subject having or at risk for psychiatric and neurodegenerative diseases. Specifically, the present invention relates to the composition comprising endoxifen in the treatment of bipolar disorder, schizophrenia, multiple sclerosis (MS), Alzheimer disease, Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), and/or epilepsy by administrating formulations or compositions comprising an effective amount of endoxifen.
• Endoxifen Compositions And Methods
  申请人：Ahmad Ateeq

  公开号：US20100112041A1

  公开（公告）日：2010-05-06

  The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E-guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.