2-Dimethylamino-methacrylnitril | 26728-79-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Dimethylamino-methacrylnitril
• 英文别名: 2-Dimethylaminomethyl-acrylnitril；2-Dimethylaminomethyl-propennitril；2-[(dimethylamino)methyl]-2-propenenitrile；2-dimethylaminomethylacrylonitrile；2-Dimethylaminomethylpropenenitrile；2-[(dimethylamino)methyl]prop-2-enenitrile
• CAS: 26728-79-0
• 化学式: C₆H₁₀N₂
• 分子量: 110.159
• InChiKey: GNNBSMZPBFKDOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Dimethylamino-methacrylnitril 在 镍 氢气 作用下， 生成 3-dimethylamino-2-methylpropanenitrile
  参考文献：
  名称：

  Adrian,G., Bulletin de la Societe Chimique de France, 1971, p. 4160 - 4169

  摘要：

  DOI：
• 作为产物：
  描述：

  1-二甲基胺-2-丙炔 生成 2-Dimethylamino-methacrylnitril
  参考文献：
  名称：

  JACKSON, W. ROY;PERIMUTTER, PATRICK;SMALLRIDGE, ANDREW J., AUSTRAL. J. CHEM., 41,(1988) N, C. 1201-1208

  摘要：

  DOI：

文献信息

• Copper-Catalyzed Intermolecular Generation of Ammonium Ylides with Subsequent [2,3]Sigmatropic Rearrangement. Efficient Synthesis of Bifunctional Homoallylamines
  作者：Kiyoshi Honda、Hiromasa Shibuya、Hiroto Yasui、Yujiro Hoshino、Seiichi Inoue

  DOI：10.1246/bcsj.81.142

  日期：2008.1.15

  The [2,3]sigmatropic rearrangement of allylic ammonium ylides generated by the reaction of N,N-dimethyl-1-alkyl-2-methylallylamines derived from terpene alcohols with diazo compounds in the presenc...

  由萜醇衍生的 N,N-二甲基-1-烷基-2-甲基烯丙胺与重氮化合物反应生成烯丙基铵叶立德的 [2,3] σ 重排...
• 3-Pyrazolidinone derivatives
  申请人：Minnesota Mining and Manufacturing Company

  公开号：US04074051A1

  公开（公告）日：1978-02-14

  3-Pyrazolidinone compounds having a solubility of at least 12 grams/liter in an aqueous medium of pH 9 of the formula: ##STR1## wherein R is a mononuclear phenyl group having substituents in the 3, 4, or 5 positions with a total of no more than 4 non-metallic atoms with an atomic number greater than 1 and the total mass of the substituents being less than that of benzene, Q is an aqueous-solubilizing group of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are independently a hydrogen, or alkyl group or together with the included nitrogen form a 5 or 6 membered heterocyclic ring composed of carbon, nitrogen and no more than one atom from the group of sulfur and oxygen, the total number of atoms in R.sup.1 and R.sup.2 having an atomic number greater than 1 being equal to or less than 6.

  3-吡唑烷酮化合物在pH为9的水性介质中的溶解度至少为每升12克，其化学式如下：其中R是一个单核苯基团，在3、4或5位置具有不超过4个非金属原子，其原子序数大于1，且取代基的总质量小于苯的质量，Q是一个具有以下化学式的水性增溶基团：其中R1和R2分别是氢、烷基基团或与所包括的氮一起形成由碳、氮组成的5或6元杂环环，其中最多有一个硫和氧原子，R1和R2中原子序数大于1的总数等于或小于6。
• Treatment of pain, fever, and inflammation with compositions containing
  申请人：Merck & Co., Inc.

  公开号：US04254131A1

  公开（公告）日：1981-03-03

  A method of treating pain, fever, and inflammation and pharmaceutical compositions for use therein, wherein the active ingredient comprises a compound of the formula: ##STR1## wherein A and R.sub.1 represent various substituents.

  一种治疗疼痛、发热和炎症的方法以及用于该方法的药物组合物，其中活性成分包括一种化合物，其化学式为：##STR1## 其中A和R.sub.1代表不同的取代基。
• 2-(Substitutedpiperidylmethyl)propene and propane nitriles
  申请人：Merck & Co., Inc.

  公开号：US04247700A1

  公开（公告）日：1981-01-27

  Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethyl-propenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaldehyde: the propane derivatives therefrom by nucleophilic addition. sp This application is a continuation-in-part of Ser. No. 795,693, filed May 11, 1977, now abandoned.

  适用于水系统中用于防止生物降解的抗微生物剂包括取代的哌啶基丙烯腈和丙腈。这些不饱和化合物是通过适当哌啶与氰乙酸和甲醛反应制备的：其丙烷衍生物通过亲核加成得到。本申请是1977年5月11日提交的第795,693号申请的续展部分，现已废弃。
• 1-Aminomethyl-2,2-diaryl-cyclopropane carboxamides
  申请人：Societe Anonyme dite: Hexachimie

  公开号：US03989722A1

  公开（公告）日：1976-11-02

  The invention relates to 1-aminomethyl-2,2-diaryl cyclopropane carboxamides of the general formula ##SPC1## In which R represents the hydrogen atom, a halogen atom or a lower alkyl group or a lower alkoxy group; R.sub.1 and R.sub.2 which may be the same or different each represent a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, in addition to which R.sub.1 and R.sub.2 together can form with the nitrogen atom to which they are attached a heterocyclic group with 5 to 7 peaks capable of containing a second hetero atom and capable of being substituted, and to their addition salts as new industrial products. These products are suitable for therapeutic application, in particular in the treatment of Parkinson's disease.

  该发明涉及一般式##SPC1##的1-氨甲基-2,2-二芳基环丙烷羧酰胺，其中R代表氢原子、卤原子或较低的烷基基团或较低的烷氧基团；R.sub.1和R.sub.2可以相同也可以不同，分别代表氢原子、较低的烷基基团、芳基或芳基烷基，另外R.sub.1和R.sub.2还可以与它们连接的氮原子形成含有5到7个峰的杂环基团，该杂环基团能够含有第二个杂原子并且能够被取代，并且其加盐物作为新的工业产品。这些产品适用于治疗应用，特别是在帕金森病的治疗中。