(Et4N)(CH3COW(CO)5) | 59610-08-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (Et4N)(CH3COW(CO)5)
• CAS: 59610-08-1
• 化学式: C₇H₃O₆W*C₈H₂₀N
• 分子量: 497.201
• InChiKey: ZRMQKDAWOQNCGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  28.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  三甘醇单甲醚 、 (Et4N)(CH3COW(CO)5) 在 乙酰氯 作用下， 以 二氯甲烷 为溶剂， 以40%的产率得到
  参考文献：
  名称：

  Synthesis of hydrophilic Fischer carbene complexes as organometallic marker and PEGylating agent for proteins

  摘要：

  Syntheses of Fischer carbene complexes with various hydrophilic tethers (4, 6a, 6b, 6c, 8a, 8b, 14a, 14b, 15 and 19) are described. The water-soluble carbene complex, 14b, was used to label and pegylate bovine serum albumin (BSA) without affecting its conformation. The red complex, 19, underwent a sharp color change to yellow on reaction with BSA, a feature that is potentially useful for developing assay methods. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2005.07.042

文献信息

• Synthesis and structure of novel, air-stable carbyne complexes of tungsten
  作者：Debasis Hazra、Dilip K. Sinha-Mahapatra、Vedavati G. Puranik、Amitabha Sarkar

  DOI：10.1016/s0022-328x(03)00044-5

  日期：2003.4

  carbyne complexes of tungsten, L(CO)2WCR/Ar, 1b–7b, where R=CH3, Ar=substituted phenyl, and LH=(2-hydroxyphenyl)-bis(3,5-dimethylpyrazolyl)methane, with L− being a tridentate, uninegative ligand, were synthesized from W(CO)6 via tetraethylammonium acylmetallate salt, as thermally stable and air-stable solids. In another complex, 8b, the aryl ring is complexed with tricarbonylchromium. Crystal structure

  钨的新费型碳炔络合物，大号（CO）2 WCR/ AR，1B -图7b，其中R = CH 3，Ar为取代的苯基，和大号H =（2-羟基苯基） -双（3， 5- dimethylpyrazolyl）甲烷，与大号-是三齿，uninegative配体，从W（CO合成）6经由四乙acylmetallate盐，如热稳定的和空气稳定的固体。在另一种络合物8b中，芳基环与三羰基铬络合。确定代表性络合物的晶体结构以确认结构分配。
• Synthesis of hydrophilic Fischer carbene complexes as organometallic marker and PEGylating agent for proteins
  作者：Debasis Samanta、Sudeshna Sawoo、Subrata Patra、Manju Ray、Michèle Salmain、Amitabha Sarkar

  DOI：10.1016/j.jorganchem.2005.07.042

  日期：2005.12

  Syntheses of Fischer carbene complexes with various hydrophilic tethers (4, 6a, 6b, 6c, 8a, 8b, 14a, 14b, 15 and 19) are described. The water-soluble carbene complex, 14b, was used to label and pegylate bovine serum albumin (BSA) without affecting its conformation. The red complex, 19, underwent a sharp color change to yellow on reaction with BSA, a feature that is potentially useful for developing assay methods. (c) 2005 Elsevier B.V. All rights reserved.