1-Fluoro-5-propan-2-ylnaphthalene | 55830-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Fluoro-5-propan-2-ylnaphthalene
• CAS: 55830-99-4
• 化学式: C₁₃H₁₃F
• 分子量: 188.245
• InChiKey: VYBGLRNNHMKOMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-异丙基呋喃 在 palladium on activated charcoal 盐酸 、 正丁基锂 、 氢气 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 1-Fluoro-5-propan-2-ylnaphthalene
  参考文献：
  名称：

  Unexpected regioselective diels-alder cycloaddition reactions between 3-fluorobenzyne and 2-alkylfurans

  摘要：

  DOI：

  10.1016/s0040-4039(00)82311-4

文献信息

• PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20180086719A1

  公开（公告）日：2018-03-29

  The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein t, R 1 , R 2 , R 3 , R 4 , and R 6 are as described herein.

  本申请提供了式I的化合物或其药学上可接受的盐、异构体、互变异构体或其混合物，其中t、R1、R2、R3、R4和R6如此处所述。
• GRIBBLE, GORDON W.;KEAVY, DANIEL J.;BRANZ, STAPHEN E.;KELLY, WILLIAM J.;P+, TETRAHEDRON LETT., 29,(1988) N 48, C. 6227-6230
  作者：GRIBBLE, GORDON W.、KEAVY, DANIEL J.、BRANZ, STAPHEN E.、KELLY, WILLIAM J.、P+

  DOI：——

  日期：——
• PRMT5 INHIBITORS AND USES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20170198006A1

  公开（公告）日：2017-07-13

  Described herein are compounds of Formula (I)-(XIII), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
• LIVER X RECEPTORS (LXR) MODULATORS
  申请人：Phenex-FXR GmbH

  公开号：US20200115357A1

  公开（公告）日：2020-04-16

  The present invention relates to sulfonamide-, sulfinamide- or sulfonimidamide containing compounds which bind to the liver X receptor (LXRa and/or LXRβ) and act preferably as inverse agonists of LXR.
• [EN] BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：GILEAD SCIENCES INC

  公开号：WO2018057805A1

  公开（公告）日：2018-03-29

  The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein t, R1, R2, R3, R4, and R6 are as described herein. The compounds of formula I selectively inhibit the activities of PI3K isoforms and are useful in therapeutic treatments, in particular in the treatment of inflammatory diseases and cancer.