(24R)-α-ethyl-5α-cholest-8(14)-en-3β-ol acetate | 14291-39-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (24R)-α-ethyl-5α-cholest-8(14)-en-3β-ol acetate
• 英文别名: 24α-Ethylcholest-8(14)-enol acetate；5α-stigmasten-(8(14))-yl-(3β)-acetate；5α-Stigmasten-(8(14))-yl-(3β)-acetat；3β-Acetoxy-5α-stigmasten-(8(14))；(10S)-3c-Acetoxy-10r.13c-dimethyl-17c-((1R:4R)-1.5-dimethyl-4-aethyl-hexyl)-(5tH.9tH)-Δ⁸⁽¹⁴⁾-tetradecahydro-1H-cyclopenta[a]phenanthren；3β-Acetoxy-24α_F-aethyl-5α-cholesten-(8(14))；Essigsaeure-[5α-stigmasten-(8(14))-yl-(3β)-ester]；[(3S,5S,9R,10S,13R,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• CAS: 14291-39-5
• 化学式: C₃₁H₅₂O₂
• 分子量: 456.753
• InChiKey: OBDWLCLHGLNWSF-DEMODBABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (24R)-α-ethyl-5α-cholest-8(14)-en-3β-ol acetate 在 盐酸 、 氯仿 、 溶剂黄146 、 铂 作用下， 生成 3β-acetoxy-5α-stigmastane
  参考文献：
  名称：

  α- and β-Spinastenol

  摘要：

  DOI：

  10.1021/ja01327a039
• 作为产物：
  描述：

  (22E,24R)-24-ethyl-5alpha-cholesta-7,22-dien-3beta-yl acetate 在 乙醚 、 溶剂黄146 、 乙酸乙酯 、 铂 作用下， 生成 (24R)-α-ethyl-5α-cholest-8(14)-en-3β-ol acetate
  参考文献：
  名称：

  271.分子旋转差异法在类固醇上的应用。第五部分。7：8位的烯烃不饱和

  摘要：

  DOI：

  10.1039/jr9480001354

文献信息

• Sterols and Other Unsaponifiable Substances in the Lipids of Shell Fishes, Crustacea and Echinoderms. XVII. Mono-unsaturated Sterol Components of the Starfish Asterina Pectinifera
  作者：Yoshiyuki Toyama、Toru Takagi

  DOI：10.1246/bcsj.29.317

  日期：1956.3

  In a continuation of the study on sterol components of Asterina pectinifera, the present study is concerned with mono-unsaturated sterol components. The steryl acetate fraction recovered from the mother liquors of the recrystallizations, which were carried out for the separation of hitodesteryl (α-spinasteryl) acetate in a previous study, was subjected to fractional crystallizations by which two fractions, Δ7-spinastenyl acetate fraction and Δ7-cholestenyl acetate fraction, were eventually separated. Accordingly it has been found that the sterol mixture of Asterina pectinifera contains Δ7-spinastenol and Δ7-cholestenol besides hitodesterol.

  在Asterina pectinifera固醇成分研究的延续中，本研究关注的是单不饱和固醇成分。在之前的研究中，为了分离hitodesteryl（α-spinasteryl）乙酸酯，进行了重结晶，从重结晶的母液中回收的乙酸固醇部分进行了分馏结晶，最终分离出两种部分，即Δ7-spinastenyl乙酸酯部分和Δ7-cholestenyl乙酸酯部分。因此，已经发现Asterina pectinifera的固醇混合物除了hitodesterol外，还含有Δ7-spinastenol和Δ7-cholestenol。
• Steroids with Double Bonds between Quaternary Carbon Atoms. III. The Structure of α-Spinasterol
  作者：Homer E. Stavely、G. Norris Bollenback

  DOI：10.1021/ja01248a042

  日期：1943.8
• The Isolation of α-Spinasterol from Alfalfa
  作者：Erhard. Fernholz、Mildred L. Moore

  DOI：10.1021/ja01878a060

  日期：1939.9
• The Sterols of Alfalfa Seed Oil. II. Isolation of β-Spinasterol and δ-Spinasterol
  作者：L. Carroll King、Charles D. Ball

  DOI：10.1021/ja01262a079

  日期：1942.10
• Heyl; Larsen, Journal of the American Pharmaceutical Association (1912), 1933, vol. 22, p. 510,511
  作者：Heyl、Larsen

  DOI：——

  日期：——