2-(1-氰基乙氧基)丙腈 | 16852-14-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(1-氰基乙氧基)丙腈
• 英文名称: β,β'-Dicyanoethyl ether
• 英文别名: 2,2'-Oxy-dipropionitril；cyanoethyl ether；bis(cyanoethyl) ether；2,2'-Oxydipropanenitrile；2-(1-cyanoethoxy)propanenitrile
• CAS: 16852-14-5
• 化学式: C₆H₈N₂O
• 分子量: 124.142
• InChiKey: XWROPIPQKNRYNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  56.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-<(trimethylsilyl)oxy>propanenitrile 生成 2-(1-氰基乙氧基)丙腈
  参考文献：
  名称：

  苯基四氟磷烷的表面活性基团包括羟基酯，-丙酮，-腈，-醚等，以及硝基醇。访问quequeques导出函数αouβ荧光

  摘要：

  已经研究了苯基四氟磷烷与仲或叔α-或β-羟基酯，酮，腈，醚和硝基衍生物的反应。在几种情况下已经确定了烷氧基氟磷烷3的形成。用MeCHFCOOEt，MeCHFCH 2 COOEt和Me 2 CFCH 2 NO 2获得了良好的分离出的含氟化合物。这些化合物容易消除HF。

  DOI：

  10.1016/s0040-4020(01)90666-0

文献信息

• Production Process of Cyanoethyl Ether
  申请人：Katsumata Taiji

  公开号：US20090143623A1

  公开（公告）日：2009-06-04

  Provided is a production process of a cyanoethyl ether by reacting an alcohol and acrylonitrile in a two-phase system of a non-ether solvent/an aqueous alkali solution.

  通过在非醚溶剂/水性碱溶液的两相体系中将醇和丙烯腈反应，提供了一种制备氰乙基醚的生产工艺。
• [EN] CONTINUOUS PROCESS FOR THE MANUFACTURE OF 3-HYDROXY PROPIONITRILE<br/>[FR] PROCEDE CONTINUE DE FABRICATION DE 3-HYDROXYPROPIONITRILE
  申请人：ROCHE VITAMINS AG

  公开号：WO2003087041A1

  公开（公告）日：2003-10-23

  A fully continuous process for the manufacture of 3-hydroxypropionitrile, which process comprises (a) an addition reaction where acrylonitrile and water are reacted in the presence of a weak base to form a reaction mixture of 3-hydroxypropionitrile, bis(cyanoethyl)ether and unreacted acrylonitrile, which mixture is continuously neutralised during the transfer to the second process step; and (b) a reactive distillation where the bis(cyanoethyl)ether contained in the reaction mixture is fragmented into 3-hydroxypropionitrile and acrylonitrile and the 3-hydroxypropionitrile is subsequently separated and isolated.

  一种用于制造3-羟基丙腈的完全连续工艺，该工艺包括（a）加成反应，其中丙烯腈和水在弱碱存在下反应，形成3-羟基丙腈、双(氰乙基)醚和未反应的丙烯腈的反应混合物，该混合物在传输到第二个工艺步骤期间被连续中和；以及（b）反应蒸馏，其中反应混合物中含有的双(氰乙基)醚被分解为3-羟基丙腈和丙烯腈，然后将3-羟基丙腈分离并隔离。
• Process for producing 3-hydroxypropionitrile
  申请人：——

  公开号：US20020040163A1

  公开（公告）日：2002-04-04

  A process for the production of 3-hydroxypropionitrile is provided. This process includes (a) reacting acrylonitrile with water at a defined molar ratio in the presence of a weak base under specific temperature and pressure conditions until a conversion in the range of about 40% to about 80% has been achieved; (b) after cooling the mixture obtained in (a), separating off its aqueous phase; (c) distilling off the acrylonitrile from the organic phase remaining after (b); (d) subjecting the mixture obtained in (c) to pyrolysis at specific temperature and pressure conditions in the presence of a basic catalyst to obtain a mixture consisting mainly of 3-hydroxypropionitrile and acrylonitrile; and (e) isolating the desired 3-hydroxypropionitrile by fractional distillation from the mixture obtained in (d). Such a process in which the basic aqueous phase and the acrylonitrile that has been distilled off are recycled represents a preferred embodiment.

  提供一种生产3-羟基丙腈的方法。该方法包括：(a)在特定的摩尔比下，在弱碱存在的条件下，将丙烯腈与水反应，直到达到约40%至约80%的转化率；(b)冷却(a)步骤得到的混合物后，分离其水相；(c)从(b)步骤后剩余的有机相中蒸馏掉丙烯腈；(d)在特定的温度和压力条件下，在碱性催化剂存在的情况下，对(c)步骤得到的混合物进行热解，以获得主要由3-羟基丙腈和丙烯腈组成的混合物；(e)通过在(d)步骤得到的混合物中进行分馏，从中分离所需的3-羟基丙腈。将基础水相和蒸馏出的丙烯腈进行回收的这种方法代表了一种首选实施方式。
• Aminopropylation of alcohols in the presence of amide or ether solvents
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP1512675A1

  公开（公告）日：2005-03-09

  This invention relates to an improved hydrogenation process for the preparation of etheramines. In the process, cyanoethylated alcohols, i.e., the reaction product of an alcohol with (meth)acrylonitrile, are contacted with hydrogen in the presence of a sponge cobalt catalyst. The improvement in the process resides in effecting the hydrogenation process utilizing a cyanoethylated alcohol feedstock contaminated with byproduct acrylonitrile and utilizing a solvent that solubilizes byproduct (meth)acrylonitrile present in the feedstock. Specific classes of solvents employed are ethers and amides.

  本发明涉及一种改进的氢化工艺，用于制备醚胺。在该过程中，氰乙基化醇，即醇与（甲）丙烯腈的反应产物，在海绵钴催化剂存在下与氢接触。该过程的改进在于，利用受到副产物丙烯腈污染的氰乙基化醇进料进行氢化过程，并利用能溶解进料中存在的副产物（甲）丙烯腈的溶剂。所采用的溶剂类别为醚和酰胺。
• Novel Artificial Rnaos Modified At The 2o-Hydroxyl Group
  申请人：Sekine Mitsuo

  公开号：US20080021206A1

  公开（公告）日：2008-01-24

  The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contribution to the production of novel functional nucleic acids. The present invention relates to a nucleoside that is represented by the general formula (I) or a nucleotide derived therefrom: wherein X and Y may be the same as or different from each other, and are hydrogen, optionally substituted silyl group, 4-methoxytrityl group, 4,4′-dimethoxytrityl group or a group represented by the general formula (II): wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and B1 represents an optionally substituted pyrimidine or purine base.

  本发明的目的是开发一种在温和条件下高效构建氰乙基醚的系统，使醚类作为功能基团赋予特定功能并为新型功能核酸的生产做出贡献。本发明涉及一种由通式（I）表示的核苷或其衍生物：其中X和Y可以相同或不同，是氢、可选取代硅基团、4-甲氧基三苯甲基基团、4,4'-二甲氧基三苯甲基基团或由通式（II）表示的基团：其中R1和R2可以相同或不同，表示具有1-7个碳原子的烷基如二异丙基，或它们结合形成环状结构，R3表示磷酸的保护基如2-氰乙基；B1表示可选取代的嘧啶或嘌呤碱基。