4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde | 159018-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde
• 英文别名: 4-[2-(2-naphthyl)-5-methyl-4-oxazolylmethoxy]benzaldehyde；4-[(5-methyl-2-naphthalen-2-yl-1,3-oxazol-4-yl)methoxy]benzaldehyde
• CAS: 159018-03-8
• 化学式: C₂₂H₁₇NO₃
• 分子量: 343.382
• InChiKey: LOTWXKBOPBKQNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.5h， 以95%的产率得到4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol
  参考文献：
  名称：

  ALKANOIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE THEREOF

  摘要：

  公开号：

  EP1357115B1
• 作为产物：
  描述：

  4-(chloromethyl)-5-methyl-2-(2-naphthyl)-1,3-oxazole 、 对羟基苯甲醛 以to give 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde的产率得到4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde
  参考文献：
  名称：

  Tetrazole derivatives, their production and use

  摘要：

  该专利描述了一类新型的四唑衍生物，其化学式表示为##STR1##其中n为1至3的整数，A是可选取的取代杂环残基，Y是二价的碳氢化合物残基，X为CH或N，或其药学上可接受的盐，该衍生物具有优异的降糖和降脂活性。

  公开号：

  US05591862A1

文献信息

• Oxazolidinedione derivatives and their use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05665748A1

  公开（公告）日：1997-09-09

  Novel 2,4-oxazolidinedione compounds of the formula: ##STR1## wherein R is a hydrocarbon residue or a heterocyclic group each of which may be substituted; Y is --CO--, --CH(OH)-- or --NR.sup.3 -- (wherein R.sup.3 is an alkyl group which may be substituted); m is 0 or 1; n is 0, 1 or 2; X is CH or N; A is bivalent straight or branched hydrocarbon chain residue having 1 to 7 carbon atoms; R.sup.1 and R.sup.2 each are hydrogen or an alkyl group, or R.sup.1 and R.sup.2 are combined with each other to form a 5- to 6-membered heterocyclic group optionally containing nitrogen; L and M each are hydrogen, or L and M are combined with each other to form a bond, or pharmaceutically acceptable salts thereof, having excellent hypoglycemic and hypolipidemic activities and are useful as anti-diabetics or hypolipidemic agents.

  2,4-噁唑烷二酮类化合物的化学式如下：##STR1## 其中R是一个烃残基或一个杂环基，每个都可以被取代；Y是--CO--，--CH(OH)--或--NR.sup.3--（其中R.sup.3是一个可以被取代的烷基）；m为0或1；n为0, 1或2；X是CH或N；A是具有1至7个碳原子的二价直链或支链烃基残基；R.sup.1和R.sup.2分别是氢或烷基，或R.sup.1和R.sup.2结合在一起形成一个含氮的5至6元杂环基；L和M分别是氢，或L和M结合在一起形成一个键，或其药用盐，具有出色的降糖和降脂活性，并可用作抗糖尿病或降脂药物。
• Alkanoic acid derivatives process for their production and use thereof
  申请人：——

  公开号：US20040058965A1

  公开（公告）日：2004-03-25

  An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula 1 wherein R 1 is an optionally substituted 5-membered aromatic heterocyclic group; X is a bond and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond and the like, ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH 2 ) n —Z 1 — (n is an integer of 1 to 8 and Z 1 is an oxygen atom and the like) and the like; ring B is a pyridine ring optionally further having 1 to 3 substituents, and the like; U is a bond and the like; W is a divalent hydrocarbon group having 1 to 20 carbon atoms; and R 3 is —OH and the like, provided that, when ring B is a benzene ring optionally further having 1 to 3 substituents, U should be a bond, or a salt thereof.

  一种可以用作糖尿病、高脂血症、糖耐量受损等预防或治疗剂的脂肪酸衍生物可以由以下式1所表示的化合物提供，其中R1是可选取代的5-成员芳香杂环基；X是键等；Q是具有1到20个碳原子的二价碳氢基团；Y是键等；环A是一种芳香环，可选择进一步具有1到3个取代基；Z是—（CH2）n—Z1—（n是1到8的整数，Z1是氧原子等）等；环B是吡啶环，可选择进一步具有1到3个取代基等；U是键等；W是具有1到20个碳原子的二价碳氢基团；R3是—OH等；但是，当环B是苯环，可选择进一步具有1到3个取代基时，U应为键，或其盐。
• Oxazolidinedione derivatives, their production and use in lowering blood sugar and lipid levels
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0612743B1

  公开（公告）日：1997-09-10
• US5591862A
  申请人：——

  公开号：US5591862A

  公开（公告）日：1997-01-07
• US5665748A
  申请人：——

  公开号：US5665748A

  公开（公告）日：1997-09-09