3,5-dibromo-N-methylaniline | 1197007-59-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,5-dibromo-N-methylaniline
• CAS: 1197007-59-2
• 化学式: C₇H₇Br₂N
• 分子量: 264.947
• InChiKey: QPERVCCWWNPWND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  全氟(2-甲基-3-氧杂己基)氟化物 、 3,5-dibromo-N-methylaniline 在 三乙胺 作用下， 以 乙二醇二甲醚 为溶剂， 反应 2.0h， 以80%的产率得到N-(3,5-dibromophenyl)-2,3,3,3-tetrafluoro-N-methyl-2-(perfluoropropoxy)propanamide
  参考文献：
  名称：

  FLUORINE-CONTAINING BORONIC ACID ESTER COMPOUND AND METHOD FOR PRODUCING SAME

  摘要：

  公开号：

  EP2325188B1

文献信息

• [EN] METHYLAMINE DERIVATIVES AS LYSYSL OXIDASE INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE LA MÉTHYLAMINE COMME INHIBITEURS DE LA LYSYL OXIDASE POUR LE TRAITEMENT DU CANCER
  申请人：THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL

  公开号：WO2017141049A1

  公开（公告）日：2017-08-24

  Provided are compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, wherein W, X, Y, Z, x, R1, R2, R3, x and n are defined in the specification. The compounds are inhibitors of lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family members (LOXL1, LOXL2, LOXL3, LOXL4) and are useful in therapy, particularly in the treatment of cancer. Also disclosed are LOX inhibitors for use in the treatment of a cancer associated with EGFR and biomarkers that predict responsiveness to a LOX inhibitor.

  提供的是Formula (I)的化合物，或其药用可接受的盐，其中W、X、Y、Z、x、R1、R2、R3、x和n在规范中有定义。这些化合物是赖氨酸氧化酶（LOX）和赖氨酸氧化酶样（LOXL）家族成员（LOXL1、LOXL2、LOXL3、LOXL4）的抑制剂，并且在治疗中很有用，特别是在癌症治疗中。还披露了用于治疗与EGFR相关的癌症的LOX抑制剂，以及预测对LOX抑制剂响应性的生物标志物。
• FLUORINE-CONTAINING POLYETHER COMPOUND AND METHOD FOR PRODUCING THE SAME
  申请人：Unimatec Co., Ltd.

  公开号：EP2280037A1

  公开（公告）日：2011-02-02

  A fluorine-containing polyether compound having the following general formula: (where R1 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or a phenyl group X is a bromine atom or an iodine atom; 1 and m each are independently an integer of 10 or more; and 1 + m is 30-200) can be produced by reaction of a fluorine-containing dicarboxylic acid fluoride compound having the following general formula: (where 1 and m each are independently an integer of 10 or more, and 1 + m is 30-200) with an aromatic amine compound having the following general formula: [where R1 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or a phenyl group, R2 is a hydrogen atom or a group represented by the general formula -SiR3R4R5 (where R3, R4 and R5 each are independently an alkyl group having 1 to 10 carbon atoms or a phenyl group) ; and X is a bromine atom or an iodine atom] preferably in the presence of pyridine or a tertiary amine compound such as triethylamine, etc.

  通式如下的含氟聚醚化合物： (其中 R1 是氢原子、具有 1 至 3 个碳原子的烷基或苯基 X 是溴原子或碘原子；1 和 m 各自独立地为 10 或更大的整数；1 + m 为 30-200)，可通过具有以下通式的含氟二羧酸氟化物化合物反应制得： (其中 1 和 m 各自独立地为 10 或更多的整数，且 1 + m 为 30-200）与具有下 列通式的芳香胺化合物反应生成： [其中 R1 是氢原子、具有 1 至 3 个碳原子的烷基或苯基，R2 是氢原子或通式 -SiR3R4R5 所代表的基团（其中 R3、R4 和 R5 各自独立地是具有 1 至 10 个碳原子的烷基或苯基）；X 是溴原子或碘原子]，最好在吡啶或叔胺化合物如三乙胺等存在下进行。
• [EN] AEROBIC OXIDATION SYSTEM CONTAINING SULFINIC ACID, SULFONIC ACID OR DERIVATIVES THEREOF AND PHOTOCATALYTIC OXIDATION METHOD THEREFOR<br/>[FR] SYSTÈME D'OXYDATION AÉROBIE CONTENANT DE L'ACIDE SULFINIQUE, DE L'ACIDE SULFONIQUE OU DES DÉRIVÉS ASSOCIÉS ET PROCÉDÉ D'OXYDATION PHOTOCATALYTIQUE CORRESPONDANT<br/>[ZH] 一种含亚磺酸、磺酸或其衍生物的需氧氧化体系及其光促氧化方法
  申请人：UNIV TSINGHUA

  公开号：WO2020155595A1

  公开（公告）日：2020-08-06

  公开了一种需氧氧化体系及其光促需氧氧化方法，该需氧氧化体系包括1)下述物质1a)～1d)的至少一种：1a)亚磺酸或其衍生物；1b)磺酸或其衍生物；1c)通过反应可以生成亚磺酸或其衍生物的化合物或混合物；1d)通过反应可以生成磺酸或其衍生物的化合物或混合物；和2)含分子氧的组分，包括氧气、含氧气的气体和可以原位生成氧分子的反应体系的原料中的至少一种。该需氧氧化体系用于氧化方法时，在光照条件下，无需添加光敏化试剂，室温下即可需氧氧化一系列化合物得到相应的氧化产物，降低了生产成本；另外，所述方法能够大幅度降低能耗，彻底解决由重金属和酸性溶剂带来的废弃物排放污染环境的问题，以及产品中金属残留的问题。
• FLUORINE-CONTAINING POLYETHER COMPOUND AND PROCESS FOR PRODUCING THE SAME
  申请人：Saito Satoru

  公开号：US20110034729A1

  公开（公告）日：2011-02-10

  A fluorine-containing polyether compound having the following general formula: (where R 1 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or a phenyl group; X is a bromine atom or an iodine atom; l and m each are independently an integer of 10 or more; and l+m is 30-200) can be produced by reaction of a fluorine-containing dicarboxylic acid fluoride compound having the following general formula: (where l and m each are independently an integer of 10 or more, and l+m is 30-200) with an aromatic amine compound having the following general formula: [where R 1 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or a phenyl group, R 2 is a hydrogen atom or a group represented by the general formula —SiR 3 R 4 R 5 (where R 3 , R 4 and R 5 each are independently an alkyl group having 1 to 10 carbon atoms or a phenyl group); and X is a bromine atom or an iodine atom] preferably in the presence of pyridine or a tertiary amine compound such as triethylamine, etc.
• FLUORINE-CONTAINING BORONIC ACID ESTER COMPOUND AND METHOD FOR PRODUCING THE SAME
  申请人：Saito Satoru

  公开号：US20110166375A1

  公开（公告）日：2011-07-07

  A fluorine-containing boronic acid ester represented by the general formula: (R 1 is a linear or branched divalent aliphatic hydrocarbon group having 2 to 10 carbon atoms, R 2 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or phenyl group, n is an integer of 1 to 3, and m is an integer of 0 to 4) having an improved solubility in organic solvents is produced by reacting a fluorine-containing 3,5-dihalogenoanilide derivative represented by the general formula: (R 2 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or phenyl group, X is a halogen atom, n is an integer of 1 to 3, and m is an integer of 0 to 4) with a dialkoxyborane represented by the general formula: (R 1 is a linear or branched divalent aliphatic hydrocarbon group having 2 to 10 carbon atoms).