<(5-hydroxy-1-naphthylenyl)oxy>acetic acid methyl ester | 95265-26-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: <(5-hydroxy-1-naphthylenyl)oxy>acetic acid methyl ester
• 英文别名: [(5-hydroxy-1-naphthalenyl)oxy]acetic acid methyl ester；Methyl 2-(5-hydroxynaphthalen-1-yl)oxyacetate
• CAS: 95265-26-2
• 化学式: C₁₃H₁₂O₄
• 分子量: 232.236
• InChiKey: CCKAEPHDPQVLHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  <(5-hydroxy-1-naphthylenyl)oxy>acetic acid methyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到<(5-hydroxy-1-naphthylenyl)oxy>acetic acid
  参考文献：
  名称：

  Development of a Selective Enzyme-Linked Immunosorbent Assay for 1-Naphthol-the Major Metabolite of Carbaryl (1-Naphthyl N-Methylcarbamate)

  摘要：

  selective enzyme-linked immunosorbent assay for 1-naphthol was developed. Eight rabbits were immunized with either [(5-hydroxy-2-naphthylenyl)oxy]acetic acid (2b)-BSA, [(5-hydroxy-1-naphthylenyl)oxy]acetic acid (4)-BSA, or 5-hydroxy-2-naphthoic acid (7)-KLH, and all sera were screened against 14 different coating antigens. From this screening procedure, five assays could be developed, using two 7-KLH antisera, 3907 and 3909. The assay with the least interference and the best reliability (7-KLH antiserum 3907, 1:9000, and coating antigen 2b-BSA, 1.5 mu g/mL) was further optimized and characterized. It showed an I-50 value of about 72 mu g/L, with a range of detection from 10 to 1000 mu g/L. There was no cross-reactivity with carbaryl, which makes this assay very suitable for the selective detection of 1-naphthol, for example, in undiluted human urine and in soil extract. The assay was tested in organic solvents and showed a tolerance of at least 10% solvent (acetone, acetonitrile, methanol).

  DOI：

  10.1021/jf00040a019
• 作为产物：
  描述：

  1,5-二羟基萘 、 溴乙酸甲酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以46%的产率得到<<5-<(methoxycarbonyl)-methoxy>-1-naphthylenyl>oxy>acetic acid methyl ester
  参考文献：
  名称：

  Development of a Selective Enzyme-Linked Immunosorbent Assay for 1-Naphthol-the Major Metabolite of Carbaryl (1-Naphthyl N-Methylcarbamate)

  摘要：

  selective enzyme-linked immunosorbent assay for 1-naphthol was developed. Eight rabbits were immunized with either [(5-hydroxy-2-naphthylenyl)oxy]acetic acid (2b)-BSA, [(5-hydroxy-1-naphthylenyl)oxy]acetic acid (4)-BSA, or 5-hydroxy-2-naphthoic acid (7)-KLH, and all sera were screened against 14 different coating antigens. From this screening procedure, five assays could be developed, using two 7-KLH antisera, 3907 and 3909. The assay with the least interference and the best reliability (7-KLH antiserum 3907, 1:9000, and coating antigen 2b-BSA, 1.5 mu g/mL) was further optimized and characterized. It showed an I-50 value of about 72 mu g/L, with a range of detection from 10 to 1000 mu g/L. There was no cross-reactivity with carbaryl, which makes this assay very suitable for the selective detection of 1-naphthol, for example, in undiluted human urine and in soil extract. The assay was tested in organic solvents and showed a tolerance of at least 10% solvent (acetone, acetonitrile, methanol).

  DOI：

  10.1021/jf00040a019

文献信息

• Naphthalenyloxy substituted carboxylic acids
  申请人：Hoffmann-La Roche Inc.

  公开号：US04539419A1

  公开（公告）日：1985-09-03

  Compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, X is hydrogen or halogen, and A is the group ##STR2## wherein R.sub.1 is hydrogen, acyl or lower alkyl, R.sub.2 is hydrogen or lower alkyl, m is an integer from 2 to 4, n is an integer from 1 to 3, and t is an integer from 1 to 5, provided that R.sub.1 is adjacent to --(CH.sub.2).sub.m [O(CH.sub.2).sub.m ].sub.n O--, and, when R.sub.2 is hydrogen, salts thereof with pharmaceutically acceptable bases, are described. The compounds of formula I are useful as agents for the treatment of allergic conditions.

  式为##STR1##的化合物，其中R为氢或较低的烷基，X为氢或卤素，A为基团##STR2##，其中R.sub.1为氢、酰基或较低的烷基，R.sub.2为氢或较低的烷基，m为2至4的整数，n为1至3的整数，t为1至5的整数，前提是R.sub.1邻接于--(CH.sub.2).sub.m [O(CH.sub.2).sub.m ].sub.n O--，当R.sub.2为氢时，其与药用可接受碱的盐被描述。式I的化合物可用作治疗过敏症状的药物。
• LEMAHIEU, R. A.
  作者：LEMAHIEU, R. A.

  DOI：——

  日期：——
• US4539419A
  申请人：——

  公开号：US4539419A

  公开（公告）日：1985-09-03
• US4594442A
  申请人：——

  公开号：US4594442A

  公开（公告）日：1986-06-10
• Development of a Selective Enzyme-Linked Immunosorbent Assay for 1-Naphthol-the Major Metabolite of Carbaryl (1-Naphthyl N-Methylcarbamate)
  作者：Petra M. Kramer、Maria-Pilar Marco、Bruce D. Hammock

  DOI：10.1021/jf00040a019

  日期：1994.4

  selective enzyme-linked immunosorbent assay for 1-naphthol was developed. Eight rabbits were immunized with either [(5-hydroxy-2-naphthylenyl)oxy]acetic acid (2b)-BSA, [(5-hydroxy-1-naphthylenyl)oxy]acetic acid (4)-BSA, or 5-hydroxy-2-naphthoic acid (7)-KLH, and all sera were screened against 14 different coating antigens. From this screening procedure, five assays could be developed, using two 7-KLH antisera, 3907 and 3909. The assay with the least interference and the best reliability (7-KLH antiserum 3907, 1:9000, and coating antigen 2b-BSA, 1.5 mu g/mL) was further optimized and characterized. It showed an I-50 value of about 72 mu g/L, with a range of detection from 10 to 1000 mu g/L. There was no cross-reactivity with carbaryl, which makes this assay very suitable for the selective detection of 1-naphthol, for example, in undiluted human urine and in soil extract. The assay was tested in organic solvents and showed a tolerance of at least 10% solvent (acetone, acetonitrile, methanol).