3-(4-hydroxy-3,5-dimethoxy-phenyl)-1-pyrrol-1-yl-propan-1-one | 1261148-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(4-hydroxy-3,5-dimethoxy-phenyl)-1-pyrrol-1-yl-propan-1-one
• 英文别名: 3-(3,5-dimethoxy-4-hydroxyphenyl)propanoylpyrrole；3-(4-hydroxy-3,5-dimethoxyphenyl)propanoylpyrrole；3-(4-hydroxy-3,5-dimethoxyphenyl)-1-pyrrol-1-ylpropan-1-one
• CAS: 1261148-00-8
• 化学式: C₁₅H₁₇NO₄
• 分子量: 275.304
• InChiKey: LTAWLNXRMOAJDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  60.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(3,4,5-三甲氧基苯基)丙酸 在 4-二甲氨基吡啶 、 aluminum (III) chloride 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.33h， 生成 3-(4-hydroxy-3,5-dimethoxy-phenyl)-1-pyrrol-1-yl-propan-1-one
  参考文献：
  名称：

  从Piper boehmeriaefolium中首次全合成两种新型酰胺生物碱

  摘要：

  3-(3,4,5-三甲氧基苯基)丙酰吡咯和3-(3,5-二甲氧基-4-羟基苯基)丙酰吡咯是两种新型酰胺生物碱，由3,4,5-三甲氧基苯甲醛经3,4,5-三甲氧基肉桂酸和相应的二氢酸。该路线简单，反应条件温和。

  DOI：

  10.3184/174751912x13263881939640
• 作为试剂：
  描述：

  silver nitrate 在 3-(4-hydroxy-3,5-dimethoxy-phenyl)-1-pyrrol-1-yl-propan-1-one 作用下， 以 水 为溶剂， 反应 2.0h， 生成 silver
  参考文献：
  名称：

  Biosynthesis of Ag nanoparticles using pedicellamide and its photocatalytic activity: An eco-friendly approach

  摘要：

  The synthesis of silver (Ag) nanoparticles using by pedicellamide (A), isolated from Piper pedicellatum C.DC leaf is demonstrated here. TEM analysis revealed that the Ag nanoparticles predominantly form spherical in shape. The compound 'A' act as a reducing, stabilizing and capping agent. The reaction mechanism was established by using density functional theory (DFT). Photocatalytic property of the Ag nanoparticles is investigated by degradation of Methyl Red (MR) dye under UV light. The kinetic, reaction mechanism and rate constant of photocatalytic degradation of MR was evaluated. The results show that Ag nanoparticles have suitable photocatalytic activity for the degradation of MR dye.

  DOI：

  10.1016/j.saa.2014.05.024

文献信息

• First Total Synthesis of Two New Amide Alkaloids from <i>Piper boehmeriaefolium</i>
  作者：Shao-Jun Shan、Hong Zhang、Xiao-Dan Wang

  DOI：10.3184/174751912x13263881939640

  日期：2012.1

  3-(3,4,5-Trimethoxyphenyl)propanoylpyrrole and 3-(3,5-dimethoxy-4-hydroxyphenyl)propanoylpyrrole, two new amide alkaloids, were prepared from 3,4,5-trimethoxybenzaldehyde via 3,4,5-trimethoxycinnamic acid and the corresponding dihydroacid. This route is simple and the reaction conditions are mild.

  3-(3,4,5-三甲氧基苯基)丙酰吡咯和3-(3,5-二甲氧基-4-羟基苯基)丙酰吡咯是两种新型酰胺生物碱，由3,4,5-三甲氧基苯甲醛经3,4,5-三甲氧基肉桂酸和相应的二氢酸。该路线简单，反应条件温和。