N-2-(4-N-(3,5-difluorobenzamido)phenyl)propyl-2-propanesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-2-(4-N-(3,5-difluorobenzamido)phenyl)propyl-2-propanesulfonamide
• 英文别名: 3,5-difluoro-N-[4-[(2R)-1-(propan-2-ylsulfonylamino)propan-2-yl]phenyl]benzamide；3,5-difluoro-N-[4-[1-(propan-2-ylsulfonylamino)propan-2-yl]phenyl]benzamide
• 化学式: C₁₉H₂₂F₂N₂O₃S
• 分子量: 396.458
• InChiKey: ACOXQYLJOQAHST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,5-二氟苯甲酰氯 、 N-[2-(4-aminophenyl)propyl]propane-2-sulfonamide 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以71%的产率得到N-2-(4-N-(3,5-difluorobenzamido)phenyl)propyl-2-propanesulfonamide
  参考文献：
  名称：

  Sulfonamide derivatives

  摘要：

  本发明涉及一种式(Ia)的化合物或其药用可接受的盐，用于治疗与谷氨酸功能不足相关的疾病，如精神疾病和神经系统疾病。

  公开号：

  US20030233015A1

文献信息

• [EN] METHOD OF TREATING COGNITIVE DECLINE DUE TO SLEEP DEPRIVATION AND STRESS<br/>[FR] METHODE DE TRAITEMENT DU DECLIN COGNITIF DU AU MANQUE DE SOMMEIL ET AU STRESS
  申请人：CORTEX PHARMA INC

  公开号：WO2004062616A2

  公开（公告）日：2004-07-29

  This invention relates to methods of use for AMPA receptor potentiator compounds and pharmaceutical compositions in the prevention and treatment of cognitive impairment as a result of acute or chronic sleep deprivation, including enhancement of receptor functioning at synapses in brain networks responsible for higher order behaviors. A still further aspect of the present invention is the use of an active agent as described above for the preparation of a medicament for the treatment of a disorder as described above.
• [EN] COMBINATION THERAPY FOR TREATMENT OF COGNITIVE DISORDERS OR PSYCHOSES<br/>[FR] POLYTHERAPIE POUR LE TRAITEMENT DE TROUBLES COGNITIFS OU DE PSYCHOSES
  申请人：LILLY CO ELI

  公开号：WO2005013961A1

  公开（公告）日：2005-02-17

  The present invention provides a method for treating a patient suffering from or susceptible to psychosis, comprising administering to said patient an effective amount of a first component which is an atypical antipsychotic and an effective amount of a second component which is an AMPA receptor potentiator, and the pharmaceutical compositions thereof. The present invention also provides a method for treating a patient suffering from or susceptible to a cognitive disorder, comprising administering to said patient an effective amount of a first component which is a drug useful in treating a cognitive disorder and an effective amount of a second component which is an AMPA receptor potentiator, and the pharmaceutical compositions thereof.
• Sulfonamide derivatives
  申请人：——

  公开号：US20030233015A1

  公开（公告）日：2003-12-18

  The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders. 1

  本发明涉及一种式(Ia)的化合物或其药用可接受的盐，用于治疗与谷氨酸功能不足相关的疾病，如精神疾病和神经系统疾病。