2,4-dimethyl-N-propan-2-ylpentan-3-amine | 54562-10-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,4-dimethyl-N-propan-2-ylpentan-3-amine
• CAS: 54562-10-6
• 化学式: C₁₀H₂₃N
• 分子量: 157.299
• InChiKey: UHSNNWYBNVQUAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 2,4-dimethyl-N-propan-2-ylpentan-3-amine 在 甲酸 作用下， 以 水 为溶剂， 生成 N,2,4-trimethyl-N-propan-2-ylpentan-3-amine
  参考文献：
  名称：

  Mengler,C.-D., Justus Liebigs Annalen der Chemie, 1974, p. 1545 - 1549

  摘要：

  DOI：
• 作为产物：
  描述：

  Isopropylidene-(1-isopropyl-2-methyl-propyl)-amine 在 镍 氢气 作用下， 150.0 ℃ 、30.0 MPa 条件下， 生成 2,4-dimethyl-N-propan-2-ylpentan-3-amine
  参考文献：
  名称：

  Mengler,C.-D., Justus Liebigs Annalen der Chemie, 1974, p. 1545 - 1549

  摘要：

  DOI：

文献信息

• [EN] PENICILLIN-BINDING PROTEIN INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINE DE LIAISON À LA PÉNICILLINE
  申请人：VENATORX PHARMACEUTICALS INC

  公开号：WO2021108023A1

  公开（公告）日：2021-06-03

  Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

  本文描述了某些含硼化合物、组合物、制剂及其作为细菌青霉素结合蛋白的跨肽酶功能调节剂和抗菌剂的用途。在某些实施例中，本文描述的化合物抑制青霉素结合蛋白。在某些实施例中，本文描述的化合物在治疗细菌感染方面是有用的。
• POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF
  申请人：GLINKA TOMASZ

  公开号：US20080318957A1

  公开（公告）日：2008-12-25

  Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.

  揭示了具有多元碱功能的化合物。这些化合物抑制细菌外流泵抑制剂，并与抗菌剂结合使用以治疗或预防细菌感染。这些组合物可以有效对抗通过外流泵机制对抗菌剂产生抗药性的细菌感染。
• POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：Gilead Sciences, Inc.

  公开号：US20160289246A1

  公开（公告）日：2016-10-06

  Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A, A′, R 1 and R 2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  揭示了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。这些化合物具有以下的化学式（Ia）：包括立体异构体和其药用可接受的盐，其中A、A′、R1和R2如本文所定义。还揭示了与制备和使用这些化合物相关的方法，以及包含这些化合物的药物组合物。
• Biodegradable lipids for the delivery of active agents
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US11071784B2

  公开（公告）日：2021-07-27

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，该阳离子脂质的脂质分子（如疏水链）中含有一个或多个可生物降解的基团。 这些阳离子脂质可掺入脂质颗粒中，用于递送核酸等活性剂。 本发明还涉及由中性脂质、能够减少聚集的脂质、本发明的阳离子脂质和可选的固醇组成的脂质颗粒。 脂质微粒可进一步包括治疗剂，如核酸。
• Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
  申请人：Arasappan Ashok

  公开号：US20070142300A1

  公开（公告）日：2007-06-21

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.