| 1417915-81-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1417915-81-1
• 化学式: C₁₉H₁₃F₃O₂
• 分子量: 330.306
• InChiKey: GYGKGBDSWXTFFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.25
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-羧甲基绕丹宁 、 在 哌啶 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 以87%的产率得到(Z)-2-(4-oxo-2-thioxo-5-((6-((3-(trifluoromethyl)benzyl)oxy)naphthalen-2-yl)methylene)thiazolidin-3-yl)acetic acid
  参考文献：
  名称：

  Synthesis and potential antibacterial activity of new rhodanine-3-acetic acid derivatives

  摘要：

  A series of rhodanine-3-acetic acid derivatives were synthesized and investigated for their antibacterial activity against gram-positive bacteria including multidrug-resistant clinical isolates. Among these compounds, 6k with a MIC of 2 mu g/mL was as active as the standard drug (norfloxacin) but less active than oxacillin against S. aureus. The compounds 6b, 6e, 6h, 6k, 6n, and 6u presented better activities against multidrug-resistant Staphylococcus aureus than the standard drugs (norfloxacin and oxacillin), especially 6k with a MIC of 1 mu g/mL. However, none of the compounds were active against gram-negative bacteria at 64 mu g/mL.

  DOI：

  10.1007/s00044-012-0417-z
• 作为产物：
  描述：

  6-羟基-2-萘甲醛 、 1-氯甲基-3-三氟甲基苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and potential antibacterial activity of new rhodanine-3-acetic acid derivatives

  摘要：

  A series of rhodanine-3-acetic acid derivatives were synthesized and investigated for their antibacterial activity against gram-positive bacteria including multidrug-resistant clinical isolates. Among these compounds, 6k with a MIC of 2 mu g/mL was as active as the standard drug (norfloxacin) but less active than oxacillin against S. aureus. The compounds 6b, 6e, 6h, 6k, 6n, and 6u presented better activities against multidrug-resistant Staphylococcus aureus than the standard drugs (norfloxacin and oxacillin), especially 6k with a MIC of 1 mu g/mL. However, none of the compounds were active against gram-negative bacteria at 64 mu g/mL.

  DOI：

  10.1007/s00044-012-0417-z