methyl 2-(5-formyl-2-thienyl)acetate | 878628-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: methyl 2-(5-formyl-2-thienyl)acetate
• 英文别名: Methyl 2-(5-formylthiophen-2-yl)acetate；methyl 2-(5-formylthiophen-2-yl)acetate
• CAS: 878628-98-9
• 化学式: C₈H₈O₃S
• mdl: MFCD22741196
• 分子量: 184.216
• InChiKey: XEPLVJGUCPMHCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  71.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-(5-formyl-2-thienyl)acetate 在 羟胺 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Identification of potent and novel small-Molecule inhibitors of caspase-3

  摘要：

  The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.024
• 作为产物：
  描述：

  2-噻吩乙酸 在 aluminum (III) chloride 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 19.67h， 生成 methyl 2-(5-formyl-2-thienyl)acetate
  参考文献：
  名称：

  [EN] HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES
  [FR] DÉRIVÉS HÉTÉROARYLE POUR LE TRAITEMENT DE MALADIES RESPIRATOIRES

  摘要：

  本发明涉及一种新型化合物，其化学式为(I)，既是磷酸二酯酶4（PDE4）酶抑制剂又是肌碱M3受体拮抗剂，以及制备这种化合物的方法、含有它们的组合物以及其治疗用途。

  公开号：

  WO2015082616A1

文献信息

• [EN] HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES<br/>[FR] DÉRIVÉS HÉTÉROARYLE POUR LE TRAITEMENT DE MALADIES RESPIRATOIRES
  申请人：CHIESI FARMA SPA

  公开号：WO2015082616A1

  公开（公告）日：2015-06-11

  The invention relates to novel compounds of formula (I) which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

  本发明涉及一种新型化合物，其化学式为(I)，既是磷酸二酯酶4（PDE4）酶抑制剂又是肌碱M3受体拮抗剂，以及制备这种化合物的方法、含有它们的组合物以及其治疗用途。
• [EN] BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR<br/>[FR] DÉRIVÉ DE BENZÈNE OU DE THIOPHÈNE ET SON UTILISATION EN TANT QU'INHIBITEUR DE LA VAP-1
  申请人：R TECH UENO LTD

  公开号：WO2009145360A1

  公开（公告）日：2009-12-03

  The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种新颖的苯衍生物或噻吩衍生物，可用作VAP-1抑制剂，或用作预防或治疗与VAP-1相关的疾病等的药物，即由以下式（I）表示的化合物：其中每个符号如本说明书中所定义，或其药学上可接受的盐。
• Novel inhibitors of tyrosinase produced by the 4-substitution of TCT
  作者：Jian Xu、Jing Liu、Xinqi Zhu、Yanying Yu、Shuwen Cao

  DOI：10.1016/j.foodchem.2016.10.140

  日期：2017.4

  investigated their inhibitory activities and mechanisms on tyrosinase by using Spectrofluorimetry, 1H and 13C NMR titration and IR spectra. The results of the fluorescence spectra and NMR titrations showed that the thiosemicarbazone moiety formed complexes with copper ions in the active center of the enzyme and played an important role in inhibiting the activities of the target compounds. The 5-functionalization

  我们合成了一系列4-或5-官能TCT衍生物（的1 - 12），并使用分光荧光法，1H和13C NMR滴定和IR光谱研究了它们对酪氨酸酶的抑制活性和机理。荧光光谱和NMR滴定的结果表明，该硫半脲酮部分在酶的活性中心与铜离子形成络合物，并在抑制目标化合物的活性中起重要作用。5-官能化降低了抑制活性，但是带有甲氧基乙酰基的4-官能化增强了抑制活性，其中甲氧基乙酰基的强大的辅助邻域协同作用增强了并促进了抑制剂硫原子之间的络合物的形成。酪氨酸酶的双铜核。
• Thiazole Derivatives Having Vap-1 Inhibitory Activity
  申请人：Inoue Takayuki

  公开号：US20080015202A1

  公开（公告）日：2008-01-17

  A compound of the formula (I): U-V-W-X-Y-Z  (I) wherein U is lower alkyl; V is —CONH— or —NR 1 CO— wherein R 1 is a hydrogen or lower alkyl; W is a bond or lower alkylene; X is a bivalent residue derived from optionally substituted thiazole; Y is a bond or lower alkylene; and Z is a group of the formula: wherein R 2 is a group of the formula: -A-B-D-E-F-G wherein A is a bond or lower alkylene; B is a bond, —NH— or D is a bond, —CS— or —CO—; E is a bond or —NH—; F is a bond, —CO—, —O— or —SO 2 —; and G is lower alkyl, optionally protected amino, —OH, phenyl, R 3 is lower alkyl, provided that when Z is a group of the formula: then G should not be amino, when Z is a group of the formula: then G should not be when Z is a group of the formula: and G is optionally protected amino, then D should be —CS—, or then A should be lower alkylene, B or E should be —NH— and F should be —CO—; or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor as well as a pharmaceutical composition and a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

  化合物的结构式（I）：U-V-W-X-Y-Z  （I），其中U为低级烷基；V为—CONH—或—NR1CO—，其中R1为氢或低级烷基；W为键或低级亚烷基；X为源自可选取代噻唑的二价残基；Y为键或低级亚烷基；Z为下式的基团：其中R2为下式的基团：-A-B-D-E-F-G，其中A为键或低级亚烷基；B为键，—NH—或D为键，—CS—或—CO—；E为键或—NH—；F为键，—CO—，—O—或—SO2—；G为低级烷基，可选的保护氨基，—OH，苯基，R3为低级烷基，但当Z为下式的基团时：则G不应为氨基；当Z为下式的基团时：则G不应为；当Z为下式的基团时：若G为可选的保护氨基，则D应为—CS—，或者A应为低级亚烷基，B或E应为—NH—，F应为—CO—；或其药学上可接受的盐，作为血管黏附蛋白-1（VAP-1）抑制剂以及用于预防或治疗VAP-1相关疾病，特别是黄斑水肿的制剂组合物和方法，该方法包括向受体施用化合物或其药学上可接受的盐的有效量等。
• BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR
  申请人：Matsukawa Tatsuya

  公开号：US20110059957A1

  公开（公告）日：2011-03-10

  The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种新型苯并衍生物或噻吩衍生物，可用作VAP-1抑制剂，或用作预防或治疗VAP-1相关疾病等药物，即由公式（I）表示的化合物：其中每个符号如本说明书所定义，或其药学上可接受的盐。