S-ethylisothiosemicarbazide hydrogeneiodide | 58255-35-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: S-ethylisothiosemicarbazide hydrogeneiodide
• 英文别名: S-Aethylisothiosemicarbazidhydrojodid
• CAS: 58255-35-9
• 化学式: C₃H₉N₃S*HI
• 分子量: 247.103
• InChiKey: XIWZUMMBBRRJGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  8.0
• 可旋转键数：
  1.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  61.9
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  nickel(II) acetate tetrahydrate 、 S-ethylisothiosemicarbazide hydrogeneiodide 在 pyridine 作用下， 以 乙醇 为溶剂， 生成 {nickel(S-ethylisothiosemicarbazide)(pyridine)2}I2
  参考文献：
  名称：

  Leovac, V. M.; Petrovic, A. F.; Lukic, S. R., Zeitschrift für anorganische und allgemeine Chemie

  摘要：

  DOI：

文献信息

• Copper(II) and molybdenum(VI) complexes of a tridentate ONN donor isothiosemicarbazone: Synthesis, characterization, X-ray, TGA and DFT
  作者：Ahad Fasihizad、Alireza Akbari、Mehdi Ahmadi、Michal Dusek、Margarida S. Henriques、Michaela Pojarova

  DOI：10.1016/j.poly.2016.05.018

  日期：2016.9

  Abstract Stable Cu(II) and Mo(VI) complexes with the Schiff base ligand 3-methoxy-2-hydroxobenzaldehyde S-ethyl-isothiosemicarbazone (H2L) were prepared in good yields. The complexes were fully characterized by analytical and spectroscopic techniques. Single-crystal X-ray crystallography reveals the copper and molybdenum complexes have distorted square planar and octahedral geometries respectively

  摘要以稳定的产率制备了具有席夫碱配体3-甲氧基-2-羟基苯甲醛S-乙基-异硫半脲（H2L）的稳定的Cu（II）和Mo（VI）配合物。通过分析和光谱技术对复合物进行了充分表征。X射线单晶晶体学分析表明，铜和钼配合物分别具有扭曲的正方形平面和八面体几何形状。H2L充当三齿ONN供体配体。配体分别以单负（酰胺）和二负（亚氨基）的形式存在于Cu（II）和Mo（VI）配合物中。配合物的热重分析表明，CuO和MoO3为残留物。通过DFT计算得出的用于结构优化和振动频率的参数与实验数据非常吻合。
• Substituted aminobenzylideneamino guanidine compounds
  申请人：American Cyanamid Company

  公开号：US03941825A1

  公开（公告）日：1976-03-02

  The preparation of 1-amino-3-(4- and 3,4-substituted benzylideneamino)guanidine and the acid addition salts thereof, and their use as intermediates in the preparation of 1,3-bis(4- and 3,4-substituted benzylideneamino)guanidines and their acid addition salts. The final compounds prepared from the present intermediates have antiprotozoal activity particularly against coccidiosis and malaria.

  1-氨基-3-(4-和3,4-取代苯基亚胺基)脲及其酸盐的制备，以及它们作为1,3-双(4-和3,4-取代苯基亚胺基)脲及其酸盐制备中间体的使用。从这些中间体制备的最终化合物具有抗原虫活性，特别是针对球虫病和疟疾。
• Substituted aminochlorobenzylamino guanidine compounds
  申请人：American Cyanamid Company

  公开号：US03992446A1

  公开（公告）日：1976-11-16

  The preparation of 1-amino-3-(4- and 3,4-substituted benzylideneamino)guanidine and the acid addition salts thereof, and their use as intermediates in the preparation of 1,3-bis-(4- and 3,4-substituted benzylideneamino)guanidines and their acid addition salts. The final compounds prepared from the present intermediates have antiprotozoal activity particularly against coccidiosis and malaria.

  1-氨基-3-(4-和3,4-取代苄亚胺基)脲及其酸加成盐的制备，以及它们作为1,3-双(4-和3,4-取代苄亚胺基)脲及其酸加成盐的中间体的用途。从当前中间体制备的最终化合物具有抗原虫活性，特别是对球虫病和疟疾。
• 3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity
  作者：Kung Ban、Sandra Duffy、Yelena Khakham、Vicky M. Avery、Andrew Hughes、Oliver Montagnat、Kasiram Katneni、Eileen Ryan、Jonathan B. Baell

  DOI：10.1016/j.bmcl.2010.08.065

  日期：2010.10

  We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum. (c) 2010 Elsevier Ltd. All rights reserved.
• Yamol'skaya, M. A.; Shames, A. I.; Gerbeleu, N. V., Russian Journal of Inorganic Chemistry, 1991, vol. 36, p. 824 - 827
  作者：Yamol'skaya, M. A.、Shames, A. I.、Gerbeleu, N. V.

  DOI：——

  日期：——