N-(4-acetylphenyl)-4-methyl-N-vinylbenzenesulfonamide | 1253375-17-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-acetylphenyl)-4-methyl-N-vinylbenzenesulfonamide
• 英文别名: N-(4-acetylphenyl)-N-ethenyl-4-methylbenzenesulfonamide
• CAS: 1253375-17-5
• 化学式: C₁₇H₁₇NO₃S
• 分子量: 315.393
• InChiKey: LMEDEDQSPHFTNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酸乙烯酯 、 N-(4-乙酰基苯基)-4-甲基苯磺酰胺 在 1,3-bis(2,4,6-tri-isopropyl-phenyl)imidazol-2-ylidene 、 palladium diacetate 、 potassium carbonate 作用下， 反应 12.0h， 以99%的产率得到N-(4-acetylphenyl)-4-methyl-N-vinylbenzenesulfonamide
  参考文献：
  名称：

  Room-temperature palladium(II)-catalyzed N-vinylation of sulfonamides and acylamides with vinyl acetate as vinyl source

  摘要：

  Room-temperature N-vinylation of various substituted sulfonamides and acylamides with vinyl acetate was achieved for the first time with a palladiumicarbene catalyst system. This reaction provides a useful method for synthesis of enamides under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.029

文献信息

• Room-temperature palladium(II)-catalyzed N-vinylation of sulfonamides and acylamides with vinyl acetate as vinyl source
  作者：Jun Xu、Yao Fu、Bin Xiao、Tianjun Gong、Qingxiang Guo

  DOI：10.1016/j.tetlet.2010.08.029

  日期：2010.10

  Room-temperature N-vinylation of various substituted sulfonamides and acylamides with vinyl acetate was achieved for the first time with a palladiumicarbene catalyst system. This reaction provides a useful method for synthesis of enamides under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.