3-tert-butyl-1-phenylindene | 95191-94-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 3-tert-butyl-1-phenylindene
• 英文别名: 3-t-butyl-1-phenylindene；3-tert-butyl-1-phenyl-1H-indene
• CAS: 95191-94-9
• 化学式: C₁₉H₂₀
• 分子量: 248.368
• InChiKey: OIJRHQAYQHNAJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  (Z)-N'-(4,4-dimethyl-1,1-diphenylpent-1-en-3-ylidene)-4-methylbenzenesulfonohydrazide 在 sodium methylate 作用下， 反应 17.5h， 生成 3-tert-butyl-1-phenylindene
  参考文献：
  名称：

  Mechanisms for interconversions among C3H4 hydrocarbons: deuterium isotope effects and independent generation of vinylmethylene intermediates in photoisomerizations of allenes and cyclopropenes

  摘要：

  DOI：

  10.1021/ja00293a047

文献信息

• The intramolecular reaction of acetophenone <i>N</i>-tosylhydrazone and vinyl: Brønsted acid-promoted cationic cyclization toward polysubstituted indenes
  作者：Zhixin Wang、Yang Li、Fan Chen、Peng-Cheng Qian、Jiang Cheng

  DOI：10.1039/d0cc07966a

  日期：——

  TsNHNH2, a Brønsted acid-promoted intramolecular cyclization of o-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydic N-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, where N-tosylhydrazone served

  在存在TsNHNH 2的情况下，开发了布朗斯台德酸促进的邻-（1-芳基乙烯基）苯乙酮衍生物的分子内环化反应，导致多取代的茚并酮具有复杂性和多样性，产率中等至优异。与自由基或卡宾涉及醛基N-甲苯磺酰hydr与乙烯基的环化形成鲜明对比，涉及阳离子环化途径，其中N-甲苯磺酰zone在该转化过程中用作亲电试剂和烷基化试剂。
• Efficient synthesis of indenes by FeCl3·6H2O-catalyzed intramolecular Friedel–Crafts reaction of aryl-substituted allylic alcohols
  作者：Jialiang Wang、Lixin Zhang、Yufeng Jing、Wen Huang、Xigeng Zhou

  DOI：10.1016/j.tetlet.2009.06.070

  日期：2009.9

  An efficient procedure for the synthesis of substituted indenes through the FeCl3 center dot 6H(2)O-catalyzed intramolecular Friedel-Crafts cyclization of aryl-substituted allylic alcohols has been developed. This method features the easily available starting materials, cheap catalyst, simple manipulation, and mild conditions. (C) 2009 Elsevier Ltd. All rights reserved.