2-isopropyl-1,3,2-dioxaphospholane-2-oxide | 15097-29-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 2-isopropyl-1,3,2-dioxaphospholane-2-oxide
• 英文别名: 2-isopropyl-2-oxo-1,3,2-dioxaphospholane；Isopropylphosphonsaeure-ethandiylester；2-i-Propyl-2-oxo-1,3,2-dioxaphospholane；2-propan-2-yl-1,3,2λ5-dioxaphospholane 2-oxide
• CAS: 15097-29-7
• 化学式: C₅H₁₁O₃P
• 分子量: 150.114
• InChiKey: LDCZQKWSLONQPG-UHFFFAOYSA-N

物化性质

• 沸点：
  197.7±7.0 °C(predicted)
• 密度：
  1.13±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-isopropyl-1,3,2-dioxaphospholane-2-oxide 在 钴 作用下， 生成 ethylene methylphosphonate
  参考文献：
  名称：

  Socol, Steven M.; Verkade, John G., Phosphorus and Sulfur and the Related Elements, 1983, vol. 18, p. 291 - 294

  摘要：

  DOI：
• 作为产物：
  描述：

  异丙基二氯磷酸 、 乙二醇 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以80%的产率得到2-isopropyl-1,3,2-dioxaphospholane-2-oxide
  参考文献：
  名称：

  Kim, Byeong Hyo; Oh, Dong Young, Phosphorus and Sulfur and the Related Elements, 1982, vol. 13, p. 337 - 344

  摘要：

  DOI：

文献信息

• Kim, Byeong Hyo; Oh, Dong Young, Phosphorus and Sulfur and the Related Elements, 1982, vol. 13, p. 337 - 344
  作者：Kim, Byeong Hyo、Oh, Dong Young

  DOI：——

  日期：——
• Evdakov,V.P.; Alipova,E.I., Journal of general chemistry of the USSR, 1967, vol. 37, p. 412 - 414
  作者：Evdakov,V.P.、Alipova,E.I.

  DOI：——

  日期：——
• A Library of Well-Defined and Water-Soluble Poly(alkyl phosphonate)s with Adjustable Hydrolysis
  作者：Thomas Wolf、Tobias Steinbach、Frederik R. Wurm

  DOI：10.1021/acs.macromol.5b00897

  日期：2015.6.23

  Poly(alkyl ethylene phosphonate)s with different alkyl side chains exhibit significant differences in their degradation behavior. Three novel 2-alkyl-2-oxo-1,3,2-dioxaphospholanes, cyclic monomers for the ring-opening polymerization (ROP) toward poly(alkyl alkylene phosphonate)s, were synthesized by 0 robust two- or three-step protocols in reasonable yields and high purity. The polymerization was promoted by the organocatalysts 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and proceeded with high control over molecular weight and narrow molecular weight distributions (D < 1.2) up to full conversion. These polymers with methyl, ethyl, and isopropyl side chains are perfectly soluble in water (up to 25 mg mL(-1)) without a temperature-dependent phase separation. They showed no toxicity against He La cells after 24 h of incubation at any tested concentration. Polymers with butyl side chains exhibit decreased solubility and concentration-dependent cloud point temperatures and show toxicity against He La cells at concentrations above 25 mu g mL(-1). The polymers showed no acetylcholinesterase inhibition. All polymers exhibited significantly different degradation times under both neutral as well as basic conditions (variation of the alkyl side chain allowed stabilities from 8 h up to 6 days).
• Socol, Steven M.; Verkade, John G., Phosphorus and Sulfur and the Related Elements, 1983, vol. 18, p. 291 - 294
  作者：Socol, Steven M.、Verkade, John G.

  DOI：——

  日期：——