2-chloro-1,1,N,N-tetramethylethylamine hydrochloride | 1484-36-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-chloro-1,1,N,N-tetramethylethylamine hydrochloride
• 英文别名: 1-chloro-2-dimethylamino-2-methylpropane hydrochloride；2-dimethylamino-2-methylpropyl chloride hydrochloride；2-methyl-2-dimethylaminopropyl chloride hydrochloride；(chloro-tert-butyl)-dimethyl-amine; hydrochloride；(2-Chlor-1,1-dimethyl-aethyl)-dimethyl-ammonium-chlorid；(Chlor-tert-butyl)-dimethyl-amin; Hydrochlorid；1-chloro-N,N,2-trimethylpropan-2-amine;hydrochloride
• CAS: 1484-36-2
• 化学式: C₆H₁₄ClN*ClH
• 分子量: 172.098
• InChiKey: XNGJEHMQLGWOBI-UHFFFAOYSA-N

物化性质

• 熔点：
  166-167 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chloro-1,1,N,N-tetramethylethylamine hydrochloride 、 1-(5-cyano-2-mercaptobenzenesulphonyl)-2-imidazolidinone 在 sodium isopropylate 作用下， 以 异丙醇 为溶剂， 反应 16.0h， 以68%的产率得到4-(2-Dimethylamino-2-methyl-propylsulfanyl)-3-(2-oxo-imidazolidine-1-sulfonyl)-benzonitrile
  参考文献：
  名称：

  Pomarnacka; Brzozowski; Gajewski, Acta poloniae pharmaceutica, 1994, vol. 51, # 4-5, p. 393 - 401

  摘要：

  DOI：
• 作为产物：
  描述：

  2-二甲氨基-2-甲基-1-丙醇 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 生成 2-chloro-1,1,N,N-tetramethylethylamine hydrochloride
  参考文献：
  名称：

  Substituted anilino-quinazoline (or quinoline) compounds and use thereof

  摘要：

  该发明涉及式（I）的酰胺衍生物，其中：G为N或CH；R1为羟基、卤素、三氟甲基、C1-6烷基和C1-6烷氧基等基团；R2和R3中的每一个为氢、卤素、C1-6烷基、C2-6烯基或C2-6炔基；R4为氢、羟基、C1-6烷基、C1-6烷氧基和C3-7环烷基等基团，或R4为式（IC）中的基团：—K—J，其中J为芳基、杂芳基或杂环烷基，K为键或氧基、亚胺基等基团；R5为氢、卤素和三氟甲基等基团；m为1-3，q为0-4；或其药学上可接受的盐或体内可水解酯；其制备方法，含有它们的药物组合物以及它们在治疗由细胞因子介导的疾病或医疗状况中的用途。

  公开号：

  US06593333B1

文献信息

• Substituted anilino-quinazoline (or quinoline) compounds and use thereof
  申请人：Astrazeneca AB

  公开号：US06593333B1

  公开（公告）日：2003-07-15

  The invention concerns amide derivatives of Formula (I), wherein: G is N or CH; R1 is a group such as hydroxy, halo, trifluoromethyl, C1-6alkyl and C1-6alkoxy; each of R2 and R3 is hydrogen, halo, C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R4 is a group such as hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy and C3-7cycloalkyl, or R4 is of the Formula (IC): —K—J, wherein J is aryl, heteroaryl or heterocyclyl and K is a bond or a group such as oxy and imino, R5 is a group such as hydrogen, halo and trifluoromethyl: m is 1-3 and q is 0-4; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  该发明涉及式（I）的酰胺衍生物，其中：G为N或CH；R1为羟基、卤素、三氟甲基、C1-6烷基和C1-6烷氧基等基团；R2和R3中的每一个为氢、卤素、C1-6烷基、C2-6烯基或C2-6炔基；R4为氢、羟基、C1-6烷基、C1-6烷氧基和C3-7环烷基等基团，或R4为式（IC）中的基团：—K—J，其中J为芳基、杂芳基或杂环烷基，K为键或氧基、亚胺基等基团；R5为氢、卤素和三氟甲基等基团；m为1-3，q为0-4；或其药学上可接受的盐或体内可水解酯；其制备方法，含有它们的药物组合物以及它们在治疗由细胞因子介导的疾病或医疗状况中的用途。
• Synthesis of 3,6-bis(aminoalkoxy)acridines and their effect on the immune system
  作者：Robert B. Angier、Ronald V. Citarella、Martin Damiani、Paul F. Fabio、Thomas L. Fields、Soon M. Kang、Yangi Lin、Howard F. Lindh、K. C. Murdock

  DOI：10.1021/jm00366a010

  日期：1983.12

  A series of 3,6-bis(aminoalkoxy)acridines (2) was prepared and shown to have a protective antiviral effect against an interferon-sensitive virus (Columbia SK) and to partially restore an antibody response to a T-cell-dependent antigen in leukemic immunosuppressed mice. The presence of circulating interferon and the stimulation of natural killer cell activity in mice was observed for 21.

  制备了一系列3,6-双（氨基烷氧基）ac啶（2），显示对干扰素敏感病毒（Columbia SK）具有保护性抗病毒作用，并部分恢复对T细胞依赖性抗原的抗体反应在白血病免疫抑制小鼠中。观察到21小鼠中循环干扰素的存在和自然杀伤细胞活性的刺激。
• Quinoline derivatives which are 5-hydroxytryptamine antagonists
  申请人：Imperial Chemical Industries PLC

  公开号：US04607039A1

  公开（公告）日：1986-08-19

  Compounds of the formula: ##STR1## wherein A stands for the radical --(CH.sub.2).sub.2 -- which may optionally be substituted by one or two (1-2C)alkyl radicals; Q stands for an oxygen or sulphur atom; R.degree. stands for a (1-4C)alkyl, (1-4C)alkoxy or cyclopropyl radical; R.sup.1 stands for a defined (3-4C)alkyl radical, a phenyl radical which may optionally bear a defined substituent, or a defined heteroaryl radical of 5 or 6 ring atoms; and R.sup.2 and R.sup.3 stand for hydrogen or a (1-2C)alkyl radical; and pharmaceutically-acceptable acid-addition salts thereof. Processes for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.

  该公式化合物为：##STR1## 其中A代表基团--(CH.sub.2).sub.2--，可以选择性地被一个或两个(1-2C)烷基基团取代；Q代表氧或硫原子；R.degree.代表(1-4C)烷基，(1-4C)烷氧基或环丙基基团；R.sup.1代表定义的(3-4C)烷基基团，一个苯基基团，该苯基基团可以选择性地带有一个定义的取代基，或者一个由5或6个环原子组成的定义的杂环基团；R.sup.2和R.sup.3代表氢或(1-2C)烷基基团；以及其药学上可接受的酸盐。制造这些化合物的方法。包括其中一种化合物和药用稀释剂或载体的药物组合物。这些化合物是5-羟色胺拮抗剂。
• N-pyrimidinyl-N-dialkylaminoalkyl ureas
  申请人：Merck & Co., Inc.

  公开号：US04144338A1

  公开（公告）日：1979-03-13

  Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a 6 membered heterocyclic substituent containing 2 or 3 heteroatoms, and also with a substituted amino alkyl group. Further substitution is also possible. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.

  基于尿素分子的有机化合物揭示了具有强效胃酸分泌抑制性能的化合物。尿素被取代为含有2个或3个杂原子的6元杂环取代基，并且还被取代为含有取代氨基烷基基团。进一步的取代也是可能的。这些化合物对胃肠道中胃酸分泌的抑制具有深远影响，并且还公开了用于此类用途的组合物。
• Pyrazine substituted ureas
  申请人：Merck & Co., Inc.

  公开号：US04215121A1

  公开（公告）日：1980-07-29

  Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a 6 membered heterocyclic substituent containing 2 or 3 heteroatoms, and also with a substituted amino alkyl group. Further substitution is also possible. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.

  本发明揭示了基于尿素分子的有机化合物，具有强大的胃分泌抑制作用。尿素被取代为含有2或3个杂原子的6元杂环取代基，并且还被取代为含有取代氨基烷基。此外，还可以进行进一步的取代。这些化合物对于抑制肠道内的胃分泌具有深远的影响，并且还揭示了用于此类用途的组合物。