2-(6-methoxy-4-oxo-2,3-dihydrochromen-3-yl)acetic acid | 133414-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(6-methoxy-4-oxo-2,3-dihydrochromen-3-yl)acetic acid
• CAS: 133414-58-1
• 化学式: C₁₂H₁₂O₅
• 分子量: 236.224
• InChiKey: YFFHKGAKRUYKGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.83
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(6-methoxy-4-oxo-2,3-dihydrochromen-3-yl)acetic acid 在 氢碘酸 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 9-hydroxy-4,4a-dihydro-5H<1>benzopyrano(4,3-c)pyridazin-3(2H)one
  参考文献：
  名称：

  Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity

  摘要：

  A new series of benzopyranopyridazinones (1b-e) either unsubstituted at the amide nitrogen or substituted by an alkyl thiourea, as well as two benzocinnolinone derivatives (2b, f) have been synthesized and tested for their antiulcer and antisecretory activity. All the test compounds showed statistically significant antiulcer properties in the EtOH model, 1b being the most active. On the contrary, in die ASA model only 1b and 1d were found weakly active. In the pylorus-ligated rat model, 1b and 1e displayed significant antisecretory activity, though only 1b proved to be able to reduce the acidity of the gastric secretion.

  DOI：

  10.1016/0223-5234(92)90116-i
• 作为产物：
  描述：

  对苯二甲醚 在 sodium hydroxide 、 三氯化铝 作用下， 以 硝基苯 为溶剂， 反应 4.0h， 生成 2-(6-methoxy-4-oxo-2,3-dihydrochromen-3-yl)acetic acid
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of 4,4a-dihydro-5H-[1]benzopyrano[4,3-c]pyridazin-3(2H)-ones bioisosters of antihypertensive and antithrombotic benzo[h]cinnolinones

  摘要：

  A series of 4,4a-dihydro-5H-[1]benzopyrano[4,3-c]pyridazin-3-(2H)-ones (2a-h), have been prepared and evaluated for their pharmacological profile as antihypertensive and antithrombotic agents. Compounds 2 were ineffective in lowering the blood pressure of spontaneously hypertensive rats (SHR), only 2c (R1 = NHCOCH3) showing a short lasting action (< 2 h). Compounds 2c and 2b (R1 = NH2) were found to be very active as antithrombotic agents in mice, being more potent than acetylsalicylic acid (ASA) taken as reference drug. Moreover, many derivatives of this class protected rats from formation of ASA or phenylbutazone (PBZ) induced ulcers, the most active being 2f (R2 = OCH3) (ED50 = 12.2 mg/kg and 25.4 mg/kg po in ASA and PBZ models, respectively).

  DOI：

  10.1016/0223-5234(90)90194-8

文献信息

• CIGNARELLA, G.;BARLOCCO, D.;CURZU, M. M.;PINNA, G. A.;CAZZULANI, P.;CASSI+, EUR. J. MED. CHEM., 25,(1990) N, C. 749-756
  作者：CIGNARELLA, G.、BARLOCCO, D.、CURZU, M. M.、PINNA, G. A.、CAZZULANI, P.、CASSI+

  DOI：——

  日期：——
• Synthesis and pharmacological evaluation of 4,4a-dihydro-5H-[1]benzopyrano[4,3-c]pyridazin-3(2H)-ones bioisosters of antihypertensive and antithrombotic benzo[h]cinnolinones
  作者：G Cignarella、D Barlocco、MM Curzu、GA Pinna、P Cazzulani、M Cassin、B Lumachi

  DOI：10.1016/0223-5234(90)90194-8

  日期：1990.11

  A series of 4,4a-dihydro-5H-[1]benzopyrano[4,3-c]pyridazin-3-(2H)-ones (2a-h), have been prepared and evaluated for their pharmacological profile as antihypertensive and antithrombotic agents. Compounds 2 were ineffective in lowering the blood pressure of spontaneously hypertensive rats (SHR), only 2c (R1 = NHCOCH3) showing a short lasting action (< 2 h). Compounds 2c and 2b (R1 = NH2) were found to be very active as antithrombotic agents in mice, being more potent than acetylsalicylic acid (ASA) taken as reference drug. Moreover, many derivatives of this class protected rats from formation of ASA or phenylbutazone (PBZ) induced ulcers, the most active being 2f (R2 = OCH3) (ED50 = 12.2 mg/kg and 25.4 mg/kg po in ASA and PBZ models, respectively).
• Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity
  作者：G Cignarella、D Barlocco、S Villa、MM Curzu、GA Pinna、A Lavezzo、A Bestetti

  DOI：10.1016/0223-5234(92)90116-i

  日期：1992.11

  A new series of benzopyranopyridazinones (1b-e) either unsubstituted at the amide nitrogen or substituted by an alkyl thiourea, as well as two benzocinnolinone derivatives (2b, f) have been synthesized and tested for their antiulcer and antisecretory activity. All the test compounds showed statistically significant antiulcer properties in the EtOH model, 1b being the most active. On the contrary, in die ASA model only 1b and 1d were found weakly active. In the pylorus-ligated rat model, 1b and 1e displayed significant antisecretory activity, though only 1b proved to be able to reduce the acidity of the gastric secretion.