2-Methyl-5-morpholin-4-yl-3-oxopyridazine-4-carbaldehyde | 154321-33-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Methyl-5-morpholin-4-yl-3-oxopyridazine-4-carbaldehyde
• CAS: 154321-33-2
• 化学式: C₁₀H₁₃N₃O₃
• 分子量: 223.232
• InChiKey: FVFLSWGQNOXUEG-UHFFFAOYSA-N

物化性质

• 沸点：
  353.0±52.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  62.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Methyl-5-morpholin-4-yl-3-oxopyridazine-4-carbaldehyde 以 乙醇 为溶剂， 反应 72.0h， 生成 2-[(2-methyl-3-oxo-5-pyrrolidin-1-ylpyridazin-4-yl)methylidene]propanedinitrile
  参考文献：
  名称：

  Matyus, Peter; Fuji, Kaoru; Tanaka, Kiyoshi, Heterocycles, 1994, vol. 37, # l, p. 171 - 174

  摘要：

  DOI：
• 作为产物：
  描述：

  5-碘-2-甲基-2,3-二氢哒嗪-3-酮 在 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 2-Methyl-5-morpholin-4-yl-3-oxopyridazine-4-carbaldehyde
  参考文献：
  名称：

  Matyus, Peter; Fuji, Kaoru; Tanaka, Kiyoshi, Heterocycles, 1994, vol. 37, # l, p. 171 - 174

  摘要：

  DOI：

文献信息

• Synthesis of ortho-Functionalized 4-Aminomethylpyridazines as Substrate-Like Semicarbazide-Sensitive Amine Oxidase Inhibitors
  作者：Norbert Haider、Iris Hochholdinger、Péter Mátyus、Andrea Wobus

  DOI：10.1248/cpb.58.964

  日期：——

  A series of 4-aminomethylpyridazines and -pyridazin-3(2H)-ones (“diaza-benzylamines”), bearing alkylamino side chains in ortho position relative to the CH2NH2 unit, was synthesized by catalytic hydrogenation of the corresponding nitriles in strongly acidic medium. N-Benzyl protecting groups either at the pyridazinone ring nitrogen or at an exocyclic nitrogen were selectively removed hydrogenolytically or by treatment with a Lewis acid. The new compounds were tested in vitro for semicarbazide-sensitive amine oxidase (SSAO) inhibitory activity and 4-(aminomethyl)-N,N′-diethylpyridazine-3,5-diamine (22) was found to be the most active representative.

  通过在强酸性介质中催化相应腈类的氢化反应，合成了一系列 4-氨基甲基哒嗪和哒嗪-3(2H)-酮（"重氮苄胺"），其烷基氨基侧链相对于 CH2NH2 单元位于正交位置。哒嗪酮环氮或环外氮上的 N-苄基保护基团通过氢解或路易斯酸处理被选择性地去除。对这些新化合物进行了半咔嗪敏感胺氧化酶（SSAO）抑制活性的体外测试，结果发现 4-（氨基甲基）-N,N′-二乙基哒嗪-3,5-二胺（22）是活性最高的代表。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• [EN] BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES<br/>[FR] COMPLEXES BIFONCTIONNELS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE TELS COMPLEXES
  申请人：NUEVOLUTION AS

  公开号：WO2011127933A1

  公开（公告）日：2011-10-20

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.