5-amino-3-isoamyl-1-isobutyl-6-nitroquinazoline-2,4(1H,3H)-dione | 101031-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-amino-3-isoamyl-1-isobutyl-6-nitroquinazoline-2,4(1H,3H)-dione
• 英文别名: 5-Amino-3-(3-methylbutyl)-1-(2-methylpropyl)-6-nitroquinazoline-2,4-dione
• CAS: 101031-80-5
• 化学式: C₁₇H₂₄N₄O₄
• 分子量: 348.402
• InChiKey: NUMIPYYEUMLFTM-UHFFFAOYSA-N

物化性质

• 沸点：
  512.9±60.0 °C(Predicted)
• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.36
• 重原子数：
  25.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  113.16
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  甲酸 、 5-amino-3-isoamyl-1-isobutyl-6-nitroquinazoline-2,4(1H,3H)-dione 在 palladium on activated charcoal 氢气 作用下， 生成 8-isoamyl-6-isobutylimidazo[4,5-f]quinazoline-7,9-(6H,8H)-dione
  参考文献：
  名称：

  Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogs of 3-isobutyl-1-methylxanthine

  摘要：

  The linear and proximal benzo-separated analogues of 7-benzyl-3-isobutyl-1-methylxanthine, 3-isobutyl-1,8-dimethylxanthine, 3-isobutyl-8-tert-butyl-1-methylxanthine, 3-isobutyl-8-(methoxymethyl)-1-methylxanthine , and 1-isoamyl-3-isobutylxanthine have been prepared and assayed as inhibitors of the peak I and peak II forms of cyclic nucleotide phosphodiesterase from pig coronary artery. Most of the benzo analogues were less effective inhibitors of these phosphodiesterases when compared to 3-isobutyl-1-methylxanthine (IBMX) even though the active sites of both enzyme forms tolerated the stretched-out xanthines. Indeed, the linear benzo-separated analogue of 7-benzyl-IBMX was a more potent inhibitor of peak I activity than was IBMX.

  DOI：

  10.1021/jm00156a013
• 作为产物：
  描述：

  3-isoamyl-1-isobutyl-5-chloro-6-nitroquinazoline-2,4-(1H,3H)-dione 在 氨 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以84%的产率得到5-amino-3-isoamyl-1-isobutyl-6-nitroquinazoline-2,4(1H,3H)-dione
  参考文献：
  名称：

  Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogs of 3-isobutyl-1-methylxanthine

  摘要：

  The linear and proximal benzo-separated analogues of 7-benzyl-3-isobutyl-1-methylxanthine, 3-isobutyl-1,8-dimethylxanthine, 3-isobutyl-8-tert-butyl-1-methylxanthine, 3-isobutyl-8-(methoxymethyl)-1-methylxanthine , and 1-isoamyl-3-isobutylxanthine have been prepared and assayed as inhibitors of the peak I and peak II forms of cyclic nucleotide phosphodiesterase from pig coronary artery. Most of the benzo analogues were less effective inhibitors of these phosphodiesterases when compared to 3-isobutyl-1-methylxanthine (IBMX) even though the active sites of both enzyme forms tolerated the stretched-out xanthines. Indeed, the linear benzo-separated analogue of 7-benzyl-IBMX was a more potent inhibitor of peak I activity than was IBMX.

  DOI：

  10.1021/jm00156a013