4-(Fmoc-氨基)-4-哌啶甲酸盐酸盐 | 368866-09-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 4-(Fmoc-氨基)-4-哌啶甲酸盐酸盐
• 中文别名: 4-(FMOC-氨基)-4-哌啶甲酸盐酸盐；4-((((9H-芴-9-基)甲氧基)羰基)氨基)哌啶-4-羧酸盐酸盐
• 英文名称: 4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}piperidine-4-carboxylic acid hydrochloride
• 英文别名: 4-(Fmoc-amino)-4-piperidinecarboxylic acid hydrochloride；4-(9H-fluoren-9-ylmethoxycarbonylamino)piperidine-4-carboxylic acid;hydrochloride
• CAS: 368866-09-5
• 化学式: C₂₁H₂₂N₂O₄*ClH
• 分子量: 402.878
• InChiKey: UDBFKLWITSYZJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  87.7
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4-(Fmoc-氨基)-4-哌啶甲酸盐酸盐 在 盐酸 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 生成
  参考文献：
  名称：

  A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool

  摘要：

  AbstractTwo types of cationic cyclic α,α‐disubstituted α‐amino acids: Api (which possesses a lysine mimic side chain) and ApiC2Gu (which possesses an arginine mimic side chain), were developed. These amino acids were incorporated into an arginine‐based peptide sequence [(l‐Arg‐l‐Arg‐dAA)3: dAA=Api or ApiC2Gu], and the relationship between the secondary structures of the resulting peptides and their ability to pass through cell membranes was investigated. The peptide containing ApiC2Gu formed a stable α‐helical structure and was more effective at penetrating cells than the nonhelical Arg nonapeptide (R9). Furthermore, the peptide was able to deliver plasmid DNA into various types of cells in a highly efficient manner.

  DOI：

  10.1002/cbic.201500468
• 作为产物：
  描述：

  1-(N-BOC)-4-(N-FMOC-氨基)-4-哌啶甲酸 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.25h， 生成 4-(Fmoc-氨基)-4-哌啶甲酸盐酸盐
  参考文献：
  名称：

  [EN] VIRAL POLYMERASE INHIBITORS
  [FR] INHIBITEURS DE POLYMÉRASE VIRALE

  摘要：

  本发明涉及式(I)的病毒聚合酶抑制剂、其盐、N-氧化物、外消旋混合物、对映异构体和同分异构体、其制备方法及其在治疗黄病毒科病毒感染，如丙型肝炎病毒(HCV)感染中的用途。

  公开号：

  WO2011153588A1

文献信息

• [EN] VIRAL POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS DE POLYMÉRASE VIRALE
  申请人：BIOTA SCIENT MANAGEMENT

  公开号：WO2011153588A1

  公开（公告）日：2011-12-15

  The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, racemates, enantiomers and isomers thereof, processes for their preparation and their use in the treatment of Flaviviridae viral infections such as Hepatitis C virus (HCV) infections.

  本发明涉及式(I)的病毒聚合酶抑制剂、其盐、N-氧化物、外消旋混合物、对映异构体和同分异构体、其制备方法及其在治疗黄病毒科病毒感染，如丙型肝炎病毒(HCV)感染中的用途。
• A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool
  作者：Hiroko Yamashita、Makoto Oba、Takashi Misawa、Masakazu Tanaka、Takayuki Hattori、Mikihiko Naito、Masaaki Kurihara、Yosuke Demizu

  DOI：10.1002/cbic.201500468

  日期：2016.1

  AbstractTwo types of cationic cyclic α,α‐disubstituted α‐amino acids: Api (which possesses a lysine mimic side chain) and ApiC2Gu (which possesses an arginine mimic side chain), were developed. These amino acids were incorporated into an arginine‐based peptide sequence [(l‐Arg‐l‐Arg‐dAA)3: dAA=Api or ApiC2Gu], and the relationship between the secondary structures of the resulting peptides and their ability to pass through cell membranes was investigated. The peptide containing ApiC2Gu formed a stable α‐helical structure and was more effective at penetrating cells than the nonhelical Arg nonapeptide (R9). Furthermore, the peptide was able to deliver plasmid DNA into various types of cells in a highly efficient manner.