6-hydroxy-5,7,8-trimethylchroman | 21704-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-hydroxy-5,7,8-trimethylchroman
• 英文别名: 5,7,8-trimethylchroman-6-ol；5,7,8-trimethyl-3,4-dihydro-2H-chromen-6-ol
• CAS: 21704-70-1
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: KXHHTQALDDOEPI-UHFFFAOYSA-N

物化性质

• 沸点：
  338.7±42.0 °C(Predicted)
• 密度：
  1.101±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-hydroxy-5,7,8-trimethylchroman 在 peroxyl radical 作用下， 生成
  参考文献：
  名称：

  Antioxidant activity of phenols related to vitamin E. Are there chain-breaking antioxidants better than .alpha.-tocopherol?

  摘要：

  DOI：

  10.1021/ja00356a057
• 作为产物：
  描述：

  2,3,5-trimethyl-6-prop-2-enylbenzene-1,4-diol 在 palladium on activated charcoal 氢气 、 三氯化铁 作用下， 以 吡啶 、 乙醇 、 乙酸乙酯 为溶剂， 50.0 ℃ 、101.33 kPa 条件下， 反应 4.0h， 生成 6-hydroxy-5,7,8-trimethylchroman
  参考文献：
  名称：

  Al-Khayat, Isam; Dean, Francis M.; France, Steven N., Journal of the Chemical Society. Perkin transactions I, 1985, p. 1301 - 1310

  摘要：

  DOI：

文献信息

• [EN] (6R,10R)-6,10,14-TRIMETYLPENTADECAN-2-ONE PREPARED FROM 6,10,14-TRIMETYLPENTADECA-5,9,13-TRIEN-2-ONE OR 6,10,14-TRIMETYLPENTADECA-5,9-DIEN-2-ONE<br/>[FR] (6R,10R)-6,10,14-TRIMÉTHYLPENTADÉCAN-2-ONE PRÉPARÉE À PARTIR DE 6,10,14-TRIMÉTHYLPENTADÉCA-5,9,13-TRIÉN-2-ONE OU DE 6,10,14-TRIMÉTHYLPENTADÉCA-5, 9-DIÉN-2-ONE
  申请人：DSM IP ASSETS BV

  公开号：WO2014096098A1

  公开（公告）日：2014-06-26

  The present invention relates to a process of manufacturing (6R,10R)- 6,10,14-trimetylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)- isomers of 6, 10, 14-trimetylpentadeca- 5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.

  本发明涉及一种从6,10,14-三甲基十五烷-2-酮的异构体混合物中，通过多步合成制备(6R,10R)-6,10,14-三甲基十五烷-2-酮的方法。该方法非常有利，因为它能够高效地从起始产物的立体异构体混合物中形成所需的手性产物。
• Method of vitamin production
  申请人：DCV Inc. doing business as Bio-Technical Resourses

  公开号：EP2305825A1

  公开（公告）日：2011-04-06

  The invention relates to methods for producing farnesol or geranylgeraniol comprising: (a) culturing a microorganism in a fermentation medium to produce a product selected from the group consisting of farnesyl phosphate and farnesol or geranylgeranyl phosphate and geranylgeraniol, wherein the action of squalene synthase of said microorganism is reduced; and (b) recovering said product.

  本发明涉及生产法呢醇或香叶基香叶醇的方法，包括：(a) 在发酵培养基中培养微生物，生产选自磷酸法呢醇和法呢醇或磷酸香叶基香叶醇和香叶基香叶醇的产物，其中所述微生物的角鲨烯合成酶的作用减弱；以及 (b) 回收所述产物。
• EPR spectra of some .alpha.-tocopherol model compounds. Polar and conformational effects and their relation to antioxidant activities
  作者：T. Doba、G. W. Burton、K. U. Ingold

  DOI：10.1021/ja00359a033

  日期：1983.10
• [EN] NOVEL USE OF SUBSTITUTED CHROMAN-6-OLS<br/>[FR] NOUVELLE UTILISATION DE CHROMAN-6-OLS SUBSTITUÉS
  申请人：DSM IP ASSETS BV

  公开号：WO2019185894A1

  公开（公告）日：2019-10-03

  The present invention is directed towards the use of substituted chroman-6- ols of formula (I) wherein R1 and R2 are independently from each other H or C1-11-alkyl or (CH2)n─OH with n being an integer from 1 to 4, or R1 and R2 represent together a keto group, 10 A is CHR3 or C(=O), and wherein R3, R4 and R6 are independently from each other H or C1-4-alkyl, and wherein R5 is H or OH or C1-4-alkyl or C1-4-alkoxy, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such substituted chroman-6-ols of formula (I).
• Al-Khayat, Isam; Dean, Francis M.; France, Steven N., Journal of the Chemical Society. Perkin transactions I, 1985, p. 1301 - 1310
  作者：Al-Khayat, Isam、Dean, Francis M.、France, Steven N.、Matkin, David A.、Orabi, Mohamed O. A.、et al.

  DOI：——

  日期：——