3β,6β-diformyloxy-5α-androst-5-ol | 1450917-20-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β,6β-diformyloxy-5α-androst-5-ol
• 英文别名: [(3S,5R,6R,8S,9S,10R,13S,14S)-6-formyloxy-5-hydroxy-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl] formate
• CAS: 1450917-20-0
• 化学式: C₂₁H₃₂O₅
• 分子量: 364.482
• InChiKey: QBQHQVVADYEPOB-KOWYNTSXSA-N

物化性质

• 沸点：
  460.5±44.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3β,6β-diformyloxy-5α-androst-5-ol 在 水 、 potassium hydroxide 作用下， 以 甲醇 为溶剂， 以49.6 g的产率得到(3beta,5alpha,6beta)-雄甾烷-3,5,6-三醇
  参考文献：
  名称：

  2ß,3a,5a-TRIHYDROXY-ANDROST-6-ONE AND PREPARATION METHODS AND USE THEREOF

  摘要：

  本发明公开了具有式(I)结构的化合物2β,3α,5α-三羟基-雄甾-6-酮。本发明还公开了制备该化合物的多种方法和该化合物的用途。

  公开号：

  US20160039862A1
• 作为产物：
  描述：

  雄甾-5-烯-3-醇 以84.9的产率得到3β,6β-diformyloxy-5α-androst-5-ol
  参考文献：
  名称：

  J. Chen et al. Steroids. 2013, 78, 996-1002

  摘要：

  DOI：

文献信息

• 2β,3α,5α-트리하이드록시-안드로스트-6-원 및 이의 제조 방법 및 이의 용도
  申请人：GUANGZHOU CELLPROTEK PHARMACEUTICAL CO., LTD. 광저우 셀프로텍 파마슈티컬 컴퍼니 리미티드(520140496337)

  公开号：KR20160021083A

  公开（公告）日：2016-02-24

  본 발명은 화학식 I의 구조를 갖는 2β,3α,5α-트리하이드록시-안드로스트-6-원 (2β,3α,5α-trihydroxy-androst-6-one) 화합물을 개시한다. 본 발명은 또한 상기 화합물의 제조를 위한 복수 개의 방법 및 상기 화합물의 용도를 개시한다. 화학식 (I).

  本发明公开了具有化学式I结构的2β,3α,5α-三羟基-雄甾-6-酮（2β,3α,5α-trihydroxy-androst-6-one）化合物。本发明还公开了用于制备上述化合物的多种方法以及上述化合物的用途。化学式（I）。
• 2 ,3 ,5 -TRIHYDROXY-ANDROST-6-ONE AND PREPARATION METHODS AND USE THEREOF
  申请人：Guangzhou Celprotek Pharmaceutical Co. Ltd.

  公开号：EP2980096A1

  公开（公告）日：2016-02-03

  The present invention discloses compound 2β,3α,5α-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also discloses a plurality of methods for preparing the compound and a use of the compound.

  本发明公开了具有式（I）结构的化合物 2β,3α,5α-三羟基雄甾-6-酮。本发明还公开了制备该化合物的多种方法以及该化合物的用途。
• A synthetic steroid 5α-androst-3β,5,6β-triol blocks hypoxia/reoxygenation-induced neuronal injuries via protection of mitochondrial function
  作者：Jiesi Chen、Tiandong Leng、Wenli Chen、Min Yan、Wei Yin、Yijun Huang、Suizhen Lin、Dayue Duan、Jun Lin、Gongxiong Wu、Jingxia Zhang、Guangmei Yan

  DOI：10.1016/j.steroids.2013.06.004

  日期：2013.10

  Ischemic stroke is a leading cause of death worldwide, yet therapies are limited. During periods of ischemia following reperfusion in ischemic stroke, not only loss of energy supply, but a few other factors including mitochondrial dysfunction and oxidative stress also make vital contribution to neuronal injury. Here we synthesized a steroid compound 5 alpha-androst-3 beta,5,6 beta-triol by 3 steps starting from dehydroepiandrosterone and examined its effect on mitochondrial function and oxidative stress in primary cultured cortical neurons exposed to hypoxia followed by reoxygenation. 5 alpha-Androst-3 beta,5,6 beta-triol dose-dependently protected cortical neurons from hypoxia/reoxygenation exposure. Rates of reduction in neuronal viability, loss of mitochondrial membrane potential, disruption of ATP production and oxidative stress were ameliorated in 5 alpha-androst-3 beta,5,6 beta-triol pretreated cultures. In summary, these results suggest that 5 alpha-androst-3 beta,5,6 beta-triol is neuroprotective against hypoxia/reoxygenation induced neuronal injuries through mediation of mitochondrial function and oxidative stress. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
• US9428539B2
  申请人：——

  公开号：US9428539B2

  公开（公告）日：2016-08-30