5-(2-(methylamino)ethoxy)quinazolin-4(3H)-one | 853002-52-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-(2-(methylamino)ethoxy)quinazolin-4(3H)-one
• 英文别名: 5-[2-(methylamino)ethoxy]quinazolin-4(3H)-one；5-[2-(methylamino)ethoxy]-3H-quinazolin-4-one
• CAS: 853002-52-5
• 化学式: C₁₁H₁₃N₃O₂
• 分子量: 219.243
• InChiKey: YYLRAKVUQHKPDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  62.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(2-(methylamino)ethoxy)quinazolin-4(3H)-one 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 19.0h， 以120 mg的产率得到4-methyl-5,6-dihydro-4H-[1,4]oxazepino[5,6,7-de]quinazoline
  参考文献：
  名称：

  An expedient synthesis of oxazepino and oxazocino quinazolines

  摘要：

  A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.10.008
• 作为产物：
  描述：

  2-氨基-6-氟苯腈 在 硫酸 、 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 4.5h， 生成 5-(2-(methylamino)ethoxy)quinazolin-4(3H)-one
  参考文献：
  名称：

  An expedient synthesis of oxazepino and oxazocino quinazolines

  摘要：

  A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.10.008

文献信息

• [EN] QUINAZOLINE DERIVATIVES<br/>[FR] DERIVES DE QUINAZOLINE
  申请人：ASTRAZENECA AB

  公开号：WO2005051923A1

  公开（公告）日：2005-06-09

  A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.

  Formula (I)的喹唑啉衍生物：其中取代基如文本中定义的那样，用于生产抗增殖效应，该效应通过在诸如人类等恒温动物中抑制erbB2受体酪氨酸激酶而产生。
• Quinazoline Derivatives
  申请人：Hennequin Francois Andre Laurent

  公开号：US20070244136A1

  公开（公告）日：2007-10-18

  A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.

  一种喹唑啉衍生物，化学式为（I），其中取代基如文本中所定义，用于制备抗增殖效应，该效应仅或部分通过抑制温血动物（例如人）中的erbB2受体酪氨酸激酶产生。
• Quinazoline derivatives
  申请人：AstraZeneca AB

  公开号：US07625908B2

  公开（公告）日：2009-12-01

  A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.

  一种喹唑啉衍生物，化学式为（I），其中取代基如文本所定义，用于制备抗增殖效应，该效应由于在温血动物（如人）中抑制erbB2受体酪氨酸激酶而产生。
• QUINAZOLINE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1685116A1

  公开（公告）日：2006-08-02
• US7625908B2
  申请人：——

  公开号：US7625908B2

  公开（公告）日：2009-12-01