8-nitro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione | 89375-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 8-nitro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione
• 英文别名: 8-nitro-2H-benzo[d][1,3]oxazin-2,4(1H)-dione；3-nitroisatoic anhydride；8-nitroisatoic anhydride；8-nitro-1H-benz[d][1,3]oxazine-2,4-dione；8-Nitro-1H-benz[d][1,3]oxazin-2,4-dion；8-nitro-1H-3,1-benzoxazine-2,4-dione
• CAS: 89375-28-0
• 化学式: C₈H₄N₂O₅
• 分子量: 208.13
• InChiKey: XKFUPFXKLACMEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-nitro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 在 盐酸 、 碳酸氢铵 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 11.25h， 生成
  参考文献：
  名称：

  Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

  摘要：

  A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by H-1 NMR, C-13 NMR, F-19 NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1-3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1-3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

  DOI：

  10.1080/10426507.2019.1661413
• 作为产物：
  描述：

  3-硝基邻苯二甲酸 在 sodium azide 、 硫酸 作用下， 生成 8-nitro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione
  参考文献：
  名称：

  Caronna, Gazzetta Chimica Italiana, 1941, vol. 71, p. 481,485

  摘要：

  DOI：

文献信息

• 표적 단백질의 분해를 유도하기 위한 데그라듀서, 이의 제조방법 및 이를 유효성분으로 함유하는 표적 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY 한국화학연구원(319980077651)

  公开号：KR20200024669A

  公开（公告）日：2020-03-09

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  本发明涉及诱导靶蛋白降解的降解酶、其制备方法以及含有其作为有效成分的用于预防或治疗靶蛋白相关疾病的药学组合物，根据本发明，化学式1所示的新化合物是利用Cereblon E3泛素连接酶，诱导靶蛋白降解的降解酶化合物，具有优异的Cereblon E3泛素连接酶结合结合活性，使得靶蛋白降解诱导活性也显著实现，从而能够将与多种疾病相关的蛋白质或多肽作为靶点，实现优异的蛋白质降解活性。根据本发明，含有化学式1所示的新化合物作为有效成分的，可提供用于预防或治疗Bromodomain-含有蛋白质相关疾病或病理的药学组合物，以及可提供用于预防或改善健康的功能性食品组合物，具有有益的效果。
• NOVEL PIPERIDINE-2,6-DIONE DERIVATIVE AND USE THEREOF
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：US20200062730A1

  公开（公告）日：2020-02-27

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  公开号：US20040077667A1

  公开（公告）日：2004-04-22

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  DOI：10.1021/acs.jafc.1c08297

  日期：2022.4.27

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  申请人：Burr Arnaud

  公开号：US20130253179A1

  公开（公告）日：2013-09-26

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