benzo[1,3]-dioxol-5-yl-(6-methyl-quinazolin-4-yl)-amine | 170449-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: benzo[1,3]-dioxol-5-yl-(6-methyl-quinazolin-4-yl)-amine
• 英文别名: 4-Anilidoquinazoline deriv. 22b；N-(1,3-benzodioxol-5-yl)-6-methylquinazolin-4-amine
• CAS: 170449-20-4
• 化学式: C₁₆H₁₃N₃O₂
• 分子量: 279.298
• InChiKey: CZJCSUFPUYPACT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  56.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-羟基-6-甲基喹唑啉 在 sodium carbonate 、 2,3-二甲基苯胺 、 三氯氧磷 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 4.5h， 生成 benzo[1,3]-dioxol-5-yl-(6-methyl-quinazolin-4-yl)-amine
  参考文献：
  名称：

  Tyrphostins IV—Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines

  摘要：

  Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0968-0896(96)00107-1

文献信息

• QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS
  申请人：GPC Biotech AG

  公开号：EP1673346A1

  公开（公告）日：2006-06-28
• Quinazoline derivatives for the treatment of herpesviral infections
  申请人：Herget Thomas

  公开号：US20070123537A1

  公开（公告）日：2007-05-31

  The present invention relates to phenyl-quinazolinyl-amine derivatives and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising at least one of these derivatives and/or pharmaceutically salts thereof, as well as the use of these derivatives for the prophylaxis and/or treatment of herpesviral induced infections, including opportunistic infections, especially for the prophylaxis and/or treatment of infections and diseases induced by HCMV.
• US7217737B2
  申请人：——

  公开号：US7217737B2

  公开（公告）日：2007-05-15
• [EN] QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS<br/>[FR] DERIVES DE QUINAZOLINE POUR LE TRAITEMENT D'INFECTIONS VIRALES HERPETIQUES
  申请人：AXXIMA PHARMACEUTICALS AG

  公开号：WO2005040125A1

  公开（公告）日：2005-05-06

  The present invention relates to phenyl-quinazolinyl-amine derivatives and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising at least one of these derivatives and/or pharmaceutically salts thereof, as well as the use of these derivatives for the prophylaxis and/or treatment of herpesviral induced infections, including opportunistic infections, especially for the prophylaxis and/or treatment of infections and diseases induced by HCMV.