ethyl 1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate | 1269792-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: ethyl 1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate
• 英文别名: ethyl 1-amino-5-[2-[(4-chlorophenyl)methylidene]hydrazinyl]-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate
• CAS: 1269792-92-8
• 化学式: C₂₁H₂₁ClN₄O₂S
• 分子量: 428.942
• InChiKey: JAKJYFIDEUYXFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.03
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  89.6
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  ethyl 1-(2-p-chlorobenzylidenehydrazinyl)-4-cyano-5,6,7,8-tetrahydroisoquinoline-3-sulfanylacetate 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 0.33h， 以73%的产率得到ethyl 1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate
  参考文献：
  名称：

  Synthesis and biological activity of pyrazolothienotetrahydroisoquinoline and [1,2,4]triazolo[3,4-a]thienotetrahydroisoquinoline derivatives

  摘要：

  1-Hydrazino-3-thioxo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (3) was subjected to react with bifunctional compounds namely: acetylacetone, ethyl cyanoacetate, ethyl benzoylactate, diethylmalonate and ethyl acetoacetate to produce pyrazololthienotetrahydroisoquinoline derivatives 6-11. Also, heating of compound (3) with formic acid afforded triazolothienotetrahydroisoquinoline compound 5 which reacted with a-halogenated compounds to afford compounds 13a-e. Compound 13c when heated with triethylorthoformate afforded triazolo derivative 14. Also, compound 6 was used for synthesizing compounds 18-20. Representative compounds of the synthesized triazolo and pyrazolothienotetrahydroisoquinoline products were tested and evaluated as antimicrobial agents. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.036