3β,16α-diacetoxy-24ξH-eburic-8-en-21-oic acid methyl ester | 30805-82-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β,16α-diacetoxy-24ξH-eburic-8-en-21-oic acid methyl ester
• 英文别名: 3β,16α-diacetoxy-24ξH-eburic-8-en-21-oic acid methyl ester；(24Ξ)-3β,16α-Diacetoxy-24-methyl-lanost-8-en-21-saeure-methylester；3β,16α-Diacetoxy-24ξH-eburic-8-en-21-saeure-methylester
• CAS: 30805-82-4
• 化学式: C₃₆H₅₈O₆
• 分子量: 586.853
• InChiKey: LCZYDQLHZAFTGI-CWOXLQJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.07
• 重原子数：
  42.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  78.9
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  3β,16α-diacetoxy-24ξH-eburic-8-en-21-oic acid methyl ester 在 selenium(IV) oxide 、 溶剂黄146 作用下， 生成 3β,16α-diacetoxy-24ξH-eburica-7,9(11)-dien-21-oic acid methyl ester
  参考文献：
  名称：

  Cort et al., Journal of the Chemical Society, 1954, p. 3713,3718

  摘要：

  DOI：
• 作为产物：
  描述：

  3β,16α-diacetoxy-eburica-8,24(28)-dien-21-oic acid methyl ester 在 溶剂黄146 、 铂 作用下， 生成 3β,16α-diacetoxy-24ξH-eburic-8-en-21-oic acid methyl ester
  参考文献：
  名称：

  Effects of vagotomy and bacterial lipopolysaccharide on food intake and expression of cyclooxygenase-2 mRNA in rat brain vessels

  摘要：

  Effects of bilateral subdiaphragmatic vagotomy on food intake and expression of cyclooxygenase-2 mRNA in cerebral vessels in rats intraperitoneally injected with bacterial lipopolysaccharide were studied using in situ hybridization technique. Low doses of lipopolysaccharide decreased food intake in sham-operated animals, but did not affect this parameter in vagotomized rats. Comparison of hybridization signals in brain slices showed that low doses of endotoxin did not affect expression of cyclooxygenase-2 mRNA in vessels of control and experimental animals. High doses of lipopolysaccharide reduced food intake in vagotomized and sham-operated rats and elevated cyclooxygenase-2 mRNA expression in vascular endothelial cells of the brain parenchyma and meninges. The data suggest that the vagus nerve activates central structures responsible for manifestation of anorexia after intraperitoneal injection of low doses of lipopolysaccharide. High doses of endotoxin activate the vagus-independent mechanism of cyclooxygenase-2 synthesis in the endothelium of cerebral vessels. It is assumed that prostaglandins synthesized by cyclooxygenase-2 diffuse into the brain parenchyma and cause anorexia by activating target nerve structures.

  DOI：

  10.1007/bf02434874