2-benzyl-hexahydro-4,7-epioxido-isoindole-1,3-dione | 1152111-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-benzyl-hexahydro-4,7-epioxido-isoindole-1,3-dione
• 英文别名: N-Benzyl-3.6-endoxo-hexahydrophthalsaeureimid；rel-(3aR,4R,7S,7aS)-Hexahydro-2-(phenylmethyl)-4,7-epoxy-1H-isoindole-1,3(2H)-dione；(3aS,4S,7R,7aR)-2-benzyl-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindole-1,3-dione
• CAS: 1152111-92-6
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.289
• InChiKey: YFPFCGVFKLMZHJ-FNFFVJSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯化苄 、 7-oxabicyclo[2.2.1]heptane-2,3-dicarboximide 在 四丁基溴化铵 、 potassium carbonate 作用下， 反应 0.03h， 以94%的产率得到2-benzyl-hexahydro-4,7-epioxido-isoindole-1,3-dione
  参考文献：
  名称：

  A NEW AND RAPID N-ALKYLATION OF 3,6-EPOXY-HEXAHYDROPHTHALIMIDES

  摘要：

  Rapid N-alkylation of 3,6-epoxyhexahydrophthalimides with a series of halides were performed under solvent-free conditions coupled with microwave irradiation. The isolated yield of N-substituted 3,6-epoxyhexahydrophthalimides varied from 82 to 98%.

  DOI：

  10.1081/scc-120002121

文献信息

• A NEW AND RAPID N-ALKYLATION OF 3,6-EPOXY-HEXAHYDROPHTHALIMIDES
  作者：Guifa Su、Xinsheng Li、Hongjing Wan

  DOI：10.1081/scc-120002121

  日期：——

  Rapid N-alkylation of 3,6-epoxyhexahydrophthalimides with a series of halides were performed under solvent-free conditions coupled with microwave irradiation. The isolated yield of N-substituted 3,6-epoxyhexahydrophthalimides varied from 82 to 98%.