3,5-二碘-4-羟基扁桃酸 | 2932-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 3,5-二碘-4-羟基扁桃酸
• 英文名称: 4-hydroxy-3,5-diiodo-mandelic acid
• 英文别名: 4-Hydroxy-3,5-dijod-mandelsaeure；3,5-Diiodo-4-hydroxymandelic Acid；2-hydroxy-2-(4-hydroxy-3,5-diiodophenyl)acetic acid
• CAS: 2932-76-5
• 化学式: C₈H₆I₂O₄
• 分子量: 419.942
• InChiKey: RAYVYAAJNUEVIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-羟基扁桃酸 在 盐酸 、 一氯化碘 作用下， 生成 3,5-二碘-4-羟基扁桃酸
  参考文献：
  名称：

  Flumazenil abolishes midazolam-induced increase in the work of nasal breathing

  摘要：

  Purpose: To evaluate the effects of midazolam sedation followed by flumazenil antagonism on the work of nasal breathing in normal humans.Methods: We measured minute ventilation through the nasal route, respiratory frequency, nasal resistance (R-n) and the work of nasal breathing under three conditions: awake, during midazolam sedation, and after flumazenil antagonism in eight healthy human subjects. A custom-made, partitioned face mask enabled nasal and oral airflow to be measured separately. To calculate R-n and the work of nasal breathing, nasal mask and oropharyngeal pressure was also measured.Results: Total resistive work spent on the upstream segment of the nasal route per minute (W-n) (J.min(-1)) was greater during midazolam sedation (3.6 +/- 2.9) than while awake (1.6 +/- 0.9) and after flumazenil antagonism (1.7 +/- 0.6), respectively (mean +/- SD) (P < 0.05). Total resistive work spent on the upstream segment of nasal breathing (W-n/V-nE) (J.L-1) increased from 0.31 +/- 0.14 to 0.75 +/- 0.61 after midazolam administration (P < 0.05) and decreased to 0.31 +/- 0.10 after flumazenil. Following midazolam administration, a strong correlation was observed between changes in W-n/V-nE and changes in (R-n r = 0.852, P < 0.0001), whereas there was no correlation between changes in W-n and changes in (R-n = 0.159, P = 0.279).Conclusion: The work of breathing spent on the upstream segment of the nasal route increases during midazolam sedation and returns to baseline after flumazenil antagonism.

  DOI：

  10.1007/bf03019871

文献信息

• Model Reactions of Thyroxine Biosynthesis. Identification of the Key Intermediates in Thyroxine Formation from 3,5-Diiodo-<scp>l</scp>-tyrosine and 4-Hydroxy-3,5-diiodophenylpyruvic Acid
  作者：Vibha B. Oza、Grzegorz M. Salamonczyk、Zhi-wei Guo、Charles J. Sih

  DOI：10.1021/ja9719034

  日期：1997.11.1