2-(1-Phenylethyl)-4-(4-piperazin-1-ylphenyl)-1,2,4-triazol-3-one | 1092481-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(1-Phenylethyl)-4-(4-piperazin-1-ylphenyl)-1,2,4-triazol-3-one
• CAS: 1092481-58-7
• 化学式: C₂₀H₂₃N₅O
• 分子量: 349.436
• InChiKey: OCHLHMMIKYHFFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(1-Phenylethyl)-4-(4-piperazin-1-ylphenyl)-1,2,4-triazol-3-one 、 2,6-二氯苯基异氰酸酯 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 N-(2,6-dichlorophenyl)-4-[4-[5-oxo-1-(1-phenylethyl)-1,2,4-triazol-4-yl]phenyl]piperazine-1-carboxamide
  参考文献：
  名称：

  WO2008/148840

  摘要：

  公开号：
• 作为产物：
  描述：

  1-氯-1-苯乙烷 在 氢氧化钾 、 水 、 氢溴酸 、 sodium hydrogensulfite 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 2-(1-Phenylethyl)-4-(4-piperazin-1-ylphenyl)-1,2,4-triazol-3-one
  参考文献：
  名称：

  WO2008/148840

  摘要：

  公开号：

文献信息

• Mtp inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles
  申请人：Meerpoel Lieven

  公开号：US20070191383A1

  公开（公告）日：2007-08-16

  The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hyper-triglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
• MTP INHIBITING ARYL PIPERIDINES OR PEPERAZINES SUBSTITUTED WITH5-MEMBERED HETEROCYCLES
  申请人：Meerpoel Lieven

  公开号：US20100004263A1

  公开（公告）日：2010-01-07

  The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
• PIPERIDINE/PIPERAZINE DERIVATIVES
  申请人：Bongartz Jean-Pierre André Marc

  公开号：US20100216809A1

  公开（公告）日：2010-08-26

  The invention further relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —NR x —C(═O)—; —Z—C(═O)—; —Z—NR x —C(═O)—; —S(═O)p-; C(═S)—; —NR x —C(═S)—; —Z—C(═S)—; —Z—NR x —C(═S)—; —O—C(═O)—; —C(═O)—C(═O)—; R 1 represents a 5-membered monocyclic heterocycle containing at least 2 heteroatoms; a 6-membered aromatic monocyclic heterocycle; or a 5-membered heterocycle containing at least 2 heteroatoms fused with phenyl, cyclohexyl or a 5-or 6-membered heterocycle; wherein each of said heterocycles may optionally be substituted; R 2 represents R 3 ; R 3 represents C 3-6 cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxlyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C 3-6 cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzo-dioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or 6-membered aromatic heterocycle may optionally be substituted; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.
• US7504400B2
  申请人：——

  公开号：US7504400B2

  公开（公告）日：2009-03-17
• US7816360B2
  申请人：——

  公开号：US7816360B2

  公开（公告）日：2010-10-19