5-(4-benzyloxy-3-methoxyphenyl)-2E,4E-pentadienoic acid piperidine amide | 77795-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-(4-benzyloxy-3-methoxyphenyl)-2E,4E-pentadienoic acid piperidine amide
• 英文别名: N-5-(4-benzyloxy-3-methxyphenyl)-2E,4E-pentadienoyl piperidine
• CAS: 77795-19-8
• 化学式: C₂₄H₂₇NO₃
• 分子量: 377.483
• InChiKey: XXJFJNBUCRMBLN-OIGXVCCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.86
• 重原子数：
  28.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.77
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  5-(4-benzyloxy-3-methoxyphenyl)-2E,4E-pentadienoic acid piperidine amide 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 生成 (2E,4E)-5-(4-hydroxy-3-methoxyphenyl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
  参考文献：
  名称：

  Inatani, Reiko; Nakatani, Nobuji; Fuwa, Hidetsugu, Agricultural and Biological Chemistry, 1981, vol. 45, # 3, p. 667 - 674

  摘要：

  DOI：
• 作为产物：
  描述：

  α-methyl-4-benzyloxy-3-methoxybenzyl alcohol 在 氢氧化钾 、 氯化亚砜 、 sodium hydride 、 三氯氧磷 作用下， 以 甲醇 、 乙二醇二甲醚 、 二氯甲烷 为溶剂， 反应 10.5h， 生成 5-(4-benzyloxy-3-methoxyphenyl)-2E,4E-pentadienoic acid piperidine amide
  参考文献：
  名称：

  Structure–activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities

  摘要：

  Inhibitors of drug metabolism have important implications in pharmaco-toxicology and agriculture. We have reported earlier that piperine, a major alkaloid of black and long peppers inhibits both constitutive and inducible cytochrome P450 (CYP)dependent drug metabolising enzymes. In the present study, an attempt has been made to prepare several novel synthetic analogues so as to relate various modifications in the parent molecule to the inhibition of CYP activities. Two types of mono-oxygenase reactions arylhydrocarbon hydroxylase (AHH) and 7-methoxycoumarin-O-demethylase (MOCD) have been studied. Inhibition studies were investigated in rat microsomal fraction prepared from untreated, 3MC- and PB- treated rat liver in vitro. Modifications were introduced into the piperine molecule: (i) in the phenyl nucleus, (ii) in the side chain and (iii) in the basic moiety. Thus, 38 compounds have been subjected to such studies, and simultaneously an attempt has also been made to arrive at the structure-activity relationship of synthetic analogues. In general, most of the inhibitory potential of the parent molecule is lost with modification in either of the three components of piperine. Saturation of the side chain resulted in significantly enhanced inhibition of CYP while modifications in the phenyl and basic moieties in few analogues offered maximal selectivity in inhibiting either constitutive or inducible CYP activities. Thus Few novel analogues as CYP inactivators have been synthesized which may have important consequences in pharmacokinetics and bioavailability of drugs. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00273-4