4-methoxybenzyl (naphth-1-yl)methyl ether | 1314564-52-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-methoxybenzyl (naphth-1-yl)methyl ether
• 英文别名: 1-(((4-methoxybenzyl)oxy)methyl)naphthalene；1-[(4-Methoxyphenyl)methoxymethyl]naphthalene
• CAS: 1314564-52-7
• 化学式: C₁₉H₁₈O₂
• 分子量: 278.351
• InChiKey: RNQLXMVWAYBKTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲氧基苄醇 在 potassium phosphate 、 dichloro(cycloocta-1,5-diene)palladium (II) 、 1,1'-bis(diisopropylphosphino)ferrocene 、 potassium hydride 作用下， 以 四氢呋喃 、 水 、 叔丁醇 为溶剂， 反应 20.0h， 生成 4-methoxybenzyl (naphth-1-yl)methyl ether
  参考文献：
  名称：

  Cross-Coupling of Mesylated Phenol Derivatives with Potassium Alkoxymethyltrifluoroborates

  摘要：

  Cross-coupling of mesylated phenol derivatives with various potassium alkoxymethyltrifluoroborates has been achieved. The corresponding aryl and heteroaryl alkoxymethyl compounds have been obtained with equal facility with both electron-rich and electron-poor substituents on the activated alcohol.

  DOI：

  10.1021/ol201469r

文献信息

• Iodine catalysed synthesis of unsymmetrical benzylic ethers by direct cross-coupling of alcohols
  作者：Balamphrang Kharrngi、Grace Basumatary、Ghanashyam Bez

  DOI：10.1016/j.tetlet.2021.153370

  日期：2021.9

  Although symmetrical ethers can be synthesized easily from alcohols, synthesis of unsymmetrical ethers by dehydrative cross-coupling of alcohols is still a challenge. While dehydrative cross-coupling is environmentally appealing due to formation of water as the only byproduct, the chances for formation of symmetrical ethers always exist. The existing transition metal based methods give good selectivity

  尽管可以很容易地从醇合成对称醚，但通过醇的脱水交叉偶联合成不对称醚仍然是一个挑战。虽然脱水交叉偶联由于形成水作为唯一的副产物而在环境上有吸引力，但形成对称醚的机会始终存在。现有的基于过渡金属的方法具有良好的选择性，但催化剂昂贵且不易获得。在这里，我们提出了一种简单、容易获得且经济有效的分子碘形式的催化剂，它催化苯甲醇与苯甲醇、烷基醇和芳基醇的高选择性交叉偶联，以良好到优异的方式生成相应的不对称醚。屈服。
• Cross-Coupling of Mesylated Phenol Derivatives with Potassium Alkoxymethyltrifluoroborates
  作者：Gary A. Molander、Floriane Beaumard

  DOI：10.1021/ol201469r

  日期：2011.8.5

  Cross-coupling of mesylated phenol derivatives with various potassium alkoxymethyltrifluoroborates has been achieved. The corresponding aryl and heteroaryl alkoxymethyl compounds have been obtained with equal facility with both electron-rich and electron-poor substituents on the activated alcohol.