4-pivaloylaminopyrimidine | 110821-14-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-pivaloylaminopyrimidine
• 英文别名: 2,2-dimethyl-N-pyrimidin-4-ylpropanamide
• CAS: 110821-14-2
• 化学式: C₉H₁₃N₃O
• 分子量: 179.222
• InChiKey: WWOQKWSKHJHGNG-UHFFFAOYSA-N

物化性质

• 沸点：
  362.2±15.0 °C(Predicted)
• 密度：
  1.130±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-pivaloylaminopyrimidine 、 正丁基锂 以 乙醚 为溶剂， 生成 2-butyl-4-pivalolylaminopyrimidine
  参考文献：
  名称：

  Synthesis of 5-Substituted Pyrimidines through ortho-Directed Lithiation Reactions

  摘要：

  DOI：

  10.3987/r-1987-03-0585
• 作为产物：
  描述：

  4-氨基嘧啶 、 三甲基乙酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 0.08h， 以72%的产率得到4-pivaloylaminopyrimidine
  参考文献：
  名称：

  5-取代的嘧啶的合成。嘧啶衍生物的邻位锂化†

  摘要：

  已经研究了一些嘧啶的邻位定向锂化。在0°下用2,2,6,6-四甲基哌啶锂在乙醚中处理2-和/或4-烷氧基或酰基氨基嘧啶，然后用各种亲电试剂淬灭，得到相应的5-取代的嘧啶。

  DOI：

  10.1002/jhet.5570270658

文献信息

• WADA, AKIMORI;YAMAMOTO, JUNPEI;KANATOMO, SHOICHI, HETEROCYCLES, 26,(1987) N 3, 585-589
  作者：WADA, AKIMORI、YAMAMOTO, JUNPEI、KANATOMO, SHOICHI

  DOI：——

  日期：——
• COMBINATION THERAPIES WITH EHMT2 INHIBITORS
  申请人：Epizyme, Inc.

  公开号：US20200054635A1

  公开（公告）日：2020-02-20

  The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.
• METHODS OF USING EHMT2 INHIBITORS
  申请人：Epizyme, Inc.

  公开号：US20200113901A1

  公开（公告）日：2020-04-16

  The present disclosure relates to a method of preventing or treating an imprinting disorder via administering an EHMT2 inhibitor compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
• AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND DERIVATIVES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20200317642A1

  公开（公告）日：2020-10-08

  The present disclosure relates to amine-substituted heterocyclic compounds and derivatives thereof. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
• Synthesis of 5-substituted pyrimidines.<i>ortho</i>-directed lithiation of pyrimidine derivatives
  作者：Akimori Wada、Junpei Yamamoto、Yuka Hamaoka、Kazuhiro Ohki、Sotoo Nagai、Shōichi Kanatomo

  DOI：10.1002/jhet.5570270658

  日期：1990.9

  ortho-Directed lithiation of some pyrimidines has been investigated. Treatment of 2- and/or 4-alkoxy or acylaminopyrimidine with lithium 2,2,6,6-tetramethylpiperidide in ether at 0°, followed by quenching with various electrophiles afforded the corresponding 5-substituted pyrimidines.

  已经研究了一些嘧啶的邻位定向锂化。在0°下用2,2,6,6-四甲基哌啶锂在乙醚中处理2-和/或4-烷氧基或酰基氨基嘧啶，然后用各种亲电试剂淬灭，得到相应的5-取代的嘧啶。