Cholest-4-en-6α-ol | 15223-01-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Cholest-4-en-6α-ol
• 英文别名: 6α-Hydroxy-cholest-4-en；Cholest-4-en-6a-ol；(6S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-ol
• CAS: 15223-01-5
• 化学式: C₂₇H₄₆O
• 分子量: 386.662
• InChiKey: ASXIELDIXZANPC-IWUBZGKGSA-N

物化性质

• 熔点：
  138-139 °C
• 沸点：
  481.9±14.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Cholest-4-en-6α-ol 在 4-二甲氨基吡啶 、 2-氯-1-甲基吡啶碘化物 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以48%的产率得到(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (6S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-6-yl ester
  参考文献：
  名称：

  Streinz, Ludvik; Valterova, Irena; Wimmer, Zdenek, Collection of Czechoslovak Chemical Communications, 1986, vol. 51, # 10, p. 2207 - 2213

  摘要：

  DOI：
• 作为产物：
  描述：

  5-hydroxy-5α-cholestan-6-one 在 吡啶 、 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 生成 Cholest-4-en-6α-ol
  参考文献：
  名称：

  Kohout,L.; Fajkos,J., Collection of Czechoslovak Chemical Communications, 1974, vol. 39, p. 1601 - 1612

  摘要：

  DOI：

文献信息

• Evaluation of Time-Resolved PM_2.5 Data in Urban/Suburban Areas of New Jersey
  作者：Nares Chuersuwan、Barbara J. Turpin、Charles Pietarinen

  DOI：10.1080/10473289.2000.10464214

  日期：2000.10

  Time-resolved data is needed for public notification of unhealthful air quality and to develop an understanding of atmospheric chemistry, including insights important to control strategies. In this research, continuous fine particulate matter (PM) mass concentrations were measured with tapered element oscillating microbalances (TEOMs) across New Jersey from July 1997 to June 1998. Data features indicating the influence of local sources and long-distance transport are examined, as well, as differences between 1-hr maxima and 24-hr average concentrations that might be relevant to acute health effects. Continuous mass concentrations were not significantly different from filter-collected gravimetric mass concentrations with 95% confidence intervals during any season. Annual mean PM2.5 concentrations from July 1997 to June 1998 were 17.3, 16.4, 14.1, and 15.3 mug/m(3) at Newark, Elizabeth, New Brunswick, and Camden, NJ, respectively. Monthly averaged 24- and 1-hr daily maximum PM2.5 concentrations suggest the existence of a high PM2.5 (May-October) and a low PM2.5 (November-April) season.PM2.5 magnitudes and temporal trends were very similar across the state during high PM, events. In fact, the between-site coefficients of determination (R-2) for daily PM2.5 measurements were 84-98% for June and July. Additionally, during the most pronounced PM2.5 episode, PM2.5 concentrations closely tracked the daily maximum 1-hr O-3 concentrations. These observations suggest the importance of transport and atmospheric chemistry (i.e., secondary formation) to PM2.5 episodes in New Jersey The influence of local sources was observed in diurnal concentration profiles and annual average between-site differences. Urban wintertime data illustrate that high 1-hr maximum PM2.5 concentrations can occur on low 24-hr PM2.5 days.
• Reaktionen mit phosphororganischen Verbindungen, 48. Mitt.
  作者：Gottfried Penz、Erich Zbiral

  DOI：10.1007/bf00905072

  日期：——
• Jones et al., Journal of the Chemical Society, 1955, p. 2876,2883
  作者：Jones et al.

  DOI：——

  日期：——
• BULL, JAMES R.;DILLEN, JAN L. M.;STEER, LYNNE M., S. AFR. J. CHEM., 40,(1987) N 3, 155-164
  作者：BULL, JAMES R.、DILLEN, JAN L. M.、STEER, LYNNE M.

  DOI：——

  日期：——