Cu(salicylate(2-))(1,10-phenanthroline) | 26143-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: Cu(salicylate(2-))(1,10-phenanthroline)
• 英文别名: Copper;2-oxidobenzoate;1,10-phenanthroline
• CAS: 26143-45-3
• 化学式: C₁₉H₁₂CuN₂O₃
• 分子量: 379.862
• InChiKey: RLRZPVJRCGNVFM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  阿司匹林 以 乙醇 为溶剂， 生成 Cu(salicylate(2-))(1,10-phenanthroline)
  参考文献：
  名称：

  Synthesis and anti-Candida activity of copper(II) and manganese(II) carboxylate complexes

  摘要：

  The copper(II) complexes [Cu(salH)(2)(H2O)(2)]. 0.5H(2)O (1) (salH(2) = salicylic acid) and [Cu-2(asp)(4)]. 3H(2)O (8) {aspH = acetylsalicylic acid (aspirin)} both react with imidazole (imid), 1,10-phenanthroline (phen) and 2,2'-bipyridine (bipy) giving [Cu(sal)(imid)] (2), [Cu(sal)(phen)] (3) and [Cu(sal)(bipy)]. C2H5OH . H2O (4), CuCl2. 2H(2)O reacts with cis-5-norbomene-eildo-2,3-dicarboxylic acid (norbH(2)) and NaOH giving [Cu(norb)]. H2O (9), Complexes 4 and 9 were crystallographically characterised. The above complexes, together with the related manganese(II) complexes, [Mn-2(salH)(4)(H2O)(4)] (5), [Mn(salH),(phen)] (6), [Mn(salH)(2)(bipy)]. H2O (7), [Mn(norb)H2O] (11) and [Mn(norb)(phen)(2)]. C2H5OH . H2O (12) and also the metal-foe ligands were screened for their ability to inhibit the growth of the pathogenic yeast Candida albicans. I,0-Phenanthroline and the phenanthroline complexes 6, 10b and 12 exhibited high anti-Candida activity with the manganese complexes 6 and 12 being the most potent. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(99)00201-6

文献信息

• Synthesis and anti-Candida activity of copper(II) and manganese(II) carboxylate complexes
  作者：Majella Geraghty、Vivienne Sheridan、Malachy McCann、Michael Devereux、Vickie McKee

  DOI：10.1016/s0277-5387(99)00201-6

  日期：1999.9

  The copper(II) complexes [Cu(salH)(2)(H2O)(2)]. 0.5H(2)O (1) (salH(2) = salicylic acid) and [Cu-2(asp)(4)]. 3H(2)O (8) aspH = acetylsalicylic acid (aspirin)} both react with imidazole (imid), 1,10-phenanthroline (phen) and 2,2'-bipyridine (bipy) giving [Cu(sal)(imid)] (2), [Cu(sal)(phen)] (3) and [Cu(sal)(bipy)]. C2H5OH . H2O (4), CuCl2. 2H(2)O reacts with cis-5-norbomene-eildo-2,3-dicarboxylic acid (norbH(2)) and NaOH giving [Cu(norb)]. H2O (9), Complexes 4 and 9 were crystallographically characterised. The above complexes, together with the related manganese(II) complexes, [Mn-2(salH)(4)(H2O)(4)] (5), [Mn(salH),(phen)] (6), [Mn(salH)(2)(bipy)]. H2O (7), [Mn(norb)H2O] (11) and [Mn(norb)(phen)(2)]. C2H5OH . H2O (12) and also the metal-foe ligands were screened for their ability to inhibit the growth of the pathogenic yeast Candida albicans. I,0-Phenanthroline and the phenanthroline complexes 6, 10b and 12 exhibited high anti-Candida activity with the manganese complexes 6 and 12 being the most potent. (C) 1999 Elsevier Science Ltd. All rights reserved.